中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
采集方式
OAI收割 [8]
内容类型
期刊论文 [8]
发表日期
2024 [2]
2022 [1]
2021 [1]
2020 [2]
2019 [2]
学科主题
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Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 14
作者:
Sun, Haiguo
;
Xi, Mengyu
;
Jin, Qiang
;
Zhu, Zhengdan
;
Zhang, Yani
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/09/30
Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11
作者:
Li, Bo
;
Li, Heng
;
Zhu, Zhengdan
;
Xiang, Caigui
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/11/04
Anti-inflammatory activity
TNF alpha
ER beta
IBD Arylisoquinolones
A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib
期刊论文
OAI收割
CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55
作者:
Chen, Gege
;
Hu, Ke
;
Sun, Haiguo
;
Zhou, Jinfeng
;
Song, Dongliang
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Multiple myeloma
Bone marrow microenvironment
DNA damage
JAK2/STAT3 pathway
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 11
作者:
Lu, Kang
;
Li, Bo
;
Zhang, Hui
;
Xu, Zhijian
;
Song, Dongliang
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Metal-free quinolylation of the primary amino groups of amino acid derivatives and peptides with dihydrooxazolo[3,2-a]quinoliniums
期刊论文
OAI收割
GREEN CHEMISTRY, 2019, 卷号: 21, 期号: 15, 页码: 4231-4237
作者:
Liu, Peng
;
Li, Bo
;
Xi, Mengyu
;
Chen, Zhaoqiang
;
Sun, Haiguo
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
期刊论文
OAI收割
CHEMISTRYOPEN, 2019, 卷号: 8, 期号: 3, 页码: 344-353
作者:
Liu, Peng
;
Chen, Xiangling
;
Zhu, Jianming
;
Li, Bo
;
Chen, Zhaoqiang
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity