中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [152]
大连化学物理研究所 [99]
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期刊论文 [869]
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物理化学 [19]
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TPN10475 Constrains Effector T Lymphocytes Activation and Attenuates Experimental Autoimmune Encephalomyelitis Pathogenesis by Facilitating TGF-β Signal Transduction
期刊论文
OAI收割
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2024, 卷号: 19, 期号: 1, 页码: 16
作者:
Wang, Chun
;
Jiang, Xiangrui
;
Lv, Jie
;
Zhuang, Wei
;
Xie, Ling
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/04/09
Experimental autoimmune encephalomyelitis
TGF-beta signal transduction
Effector CD4(+) T cells activation
Th/Treg
Cell migration
A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024, 页码: 5
作者:
Liu, Yingqiang
;
Tong, Linjiang
;
Zhang, Mengge
;
Zhang, Qi
;
Liu, Qiupei
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/13
Qing-Zhi-Tiao-Gan-Tang (QZTGT) prevents nonalcoholic steatohepatitis (NASH) by expression pattern correction
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 317, 页码: 14
作者:
Chu, Hang
;
Zhang, Weitao
;
Tan, Yan
;
Diao, Zhipeng
;
Li, Peng
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
Fibrosis
Inflammation
Lipogenesis
NASH
QZTGT
TMNP
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 卷号: 125, 页码: 13
作者:
Wang, Chun
;
Han, Mengyao
;
Li, Xinhang
;
Lv, Jie
;
Zhuang, Wei
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/01/16
AIH
T cell
Pro-inflammatory
IFN-gamma
PI3K-AKT
Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
期刊论文
OAI收割
BMC MEDICINE, 2023, 卷号: 21, 期号: 1, 页码: 13
作者:
Liu, Ting
;
Dong, Di
;
Zhao, Xun
;
Ou, Xiao-Min
;
Yi, Jun-Lin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/22
Recurrent nasopharyngeal carcinoma
Re-radiotherapy
Nasopharyngeal necrosis
Radiomics
Design and synthesis of 1H-pyrazolo[3,4-
d
]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18
作者:
Zhang, Junjie
;
Li, Yan
;
Tang, Haotian
;
Zhou, Qianqian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/08
Cancer immunotherapy
HPK1
Structure -based design
HPK1 inhibitor
A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease
期刊论文
OAI收割
WORLD JOURNAL OF PEDIATRICS, 2023, 页码: 12
作者:
Sun, Shu-Na
;
Zhou, Yan
;
Fu, Xing
;
Zheng, Yuan-Zheng
;
Xie, Cao
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3KAkt-NF-kappa B pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14
作者:
Wu, Chun-mei
;
Mao, Jia-wen
;
Zhu, Jin-zhi
;
Xie, Can-can
;
Yao, Jia-ying
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
dry eye disease
DZ2002
corneal angiogenesis
immunomodulatory function
NF-kappa B
ophthalmic therapy