中国科学院机构知识库网格
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CRISPR/Cas12a controlled chemiluminescence resonance energy transfer sensor for detection of carcinoembryonic antigen
期刊论文
OAI收割
SENSORS AND ACTUATORS B-CHEMICAL, 2024, 卷号: 401, 页码: 7
作者:
Zhou, Yanmei
;
Xie, Shupu
;
Li, Mingjie
;
Xin, Liantao
;
Zhang, Xiaoru
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/04/07
CRET
Hemin/G-quadruplexes
CRISPR/Cas12a
CEA
A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024, 页码: 5
作者:
Liu, Yingqiang
;
Tong, Linjiang
;
Zhang, Mengge
;
Zhang, Qi
;
Liu, Qiupei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/13
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
期刊论文
OAI收割
BMC MEDICINE, 2023, 卷号: 21, 期号: 1, 页码: 13
作者:
Liu, Ting
;
Dong, Di
;
Zhao, Xun
;
Ou, Xiao-Min
;
Yi, Jun-Lin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/22
Recurrent nasopharyngeal carcinoma
Re-radiotherapy
Nasopharyngeal necrosis
Radiomics
Ionospheric Super Bubbles Near Sunset and Sunrise During the 26-28 February 2023 Geomagnetic Storm
期刊论文
OAI收割
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS, 2023, 卷号: 128, 期号: 11, 页码: 17
作者:
Sun, Wenjie
;
Li, Guozhu
;
Lei, Jiuhou
;
Zhao, Biqiang
;
Hu, Lianhuan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/02
plasma bubble
ionospheric irregularity
scintillation
geomagnetic storm
GNSS
positioning
Neoproterozoic tectonic transition from subduction to back-arc extension along the western Yangtze Block, South China: Petrological evidence of Nb-enriched basalts and arc-type intrusive rocks
期刊论文
OAI收割
GONDWANA RESEARCH, 2023, 卷号: 122, 页码: 163-180
作者:
Zhu, Yu
;
Lai, Shao-Cong
;
Xie, Wan-li
;
Qin, Jiang-feng
;
Zhu, Ren-zhi
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/13
Nb-enriched basalt
Arc-type gabbros and diorites
Western Yangtze Block
Neoproterozoic
Subduction-related back-arc extension
Wavelike Structures of E-Region Irregularities Observed by All-Sky Radar at Low Latitude
期刊论文
OAI收割
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS, 2023, 卷号: 128, 期号: 10, 页码: 13
作者:
Sun, Wenjie
;
Li, Guozhu
;
Han, Chenying
;
Hu, Lianhuan
;
Li, Yi
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2023/12/27
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3KAkt-NF-kappa B pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14
作者:
Wu, Chun-mei
;
Mao, Jia-wen
;
Zhu, Jin-zhi
;
Xie, Can-can
;
Yao, Jia-ying
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
dry eye disease
DZ2002
corneal angiogenesis
immunomodulatory function
NF-kappa B
ophthalmic therapy
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran