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Chinese Academy of Sciences Institutional Repositories Grid
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上海应用物理研究... [284]
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Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1
H
)-one Analogues as Potent TRK Inhibitors for Cancer Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183
作者:
Xu, Zichao
;
Peng, Xia
;
Zhang, Renjie
;
Ji, Yinchun
;
You, Mengke
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/02/27
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation
期刊论文
OAI收割
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13
作者:
Feng, Dazhi
;
Liu, Bo
;
Chen, Zhiwei
;
Xu, Jinyi
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/02/27
HPK1 inhibitor
machine learning
virtual screening
free energy perturbation
structural modification
Characteristics and Influence Factors of Soil Water and Salt Movement in the Yellow River Irrigation District
期刊论文
OAI收割
AGRONOMY-BASEL, 2024, 卷号: 14, 期号: 1, 页码: 22
作者:
He, Kangkang
;
Zhang, Qiuying
;
Ai, Zhipin
;
Xu, Ning
;
Qiao, Yunfeng
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/01
brackish water irrigation
climate change
food security
groundwater level
salt movement
Small-scale heterogeneities at the bottom of the lower mantle beneath the northern Bay of Bengal and the northern Gulf of Mexico by the analysis of PKP precursors
期刊论文
OAI收割
GEOPHYSICAL JOURNAL INTERNATIONAL, 2023, 卷号: 236, 期号: 2, 页码: 819-833
作者:
Guan, Yurui
;
Zhang, Baolong
;
Lu, Yan
;
Hao, Jinlai
;
Li, Juan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/01/09
Composition and structure of the mantle
Body waves
Wave scattering and diffraction
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Vehicle dynamic dispatching using curriculum-driven reinforcement learning
期刊论文
OAI收割
MECHANICAL SYSTEMS AND SIGNAL PROCESSING, 2023, 卷号: 204, 页码: 16
作者:
Zhang, Xiaotong
;
Xiong, Gang
;
Ai, Yunfeng
;
Liu, Kunhua
;
Chen, Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/26
Reinforcement learning
Curriculum learning
Vehicle dispatching
Network optimization
Machine learning model for predicting physical activity related bleeding risk in Chinese boys with haemophilia A
期刊论文
OAI收割
THROMBOSIS RESEARCH, 2023, 卷号: 232, 页码: 43-53
作者:
Ai, Di
;
Cui, Chang
;
Tang, Yongqiang
;
Wang, Yan
;
Zhang, Ningning
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/26
Haemophilia
Children
Machine learning
Bleeding predictive modelling
Physical activity
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 23, 页码: 16201-16221
作者:
Xie, Chenghu
;
Liu, Bo
;
Song, Zilan
;
Yang, Ye
;
Dai, Mengdi
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/02/27
Genome-wide epigenetic dynamics during postnatal skeletal muscle growth in Hu sheep
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2023, 卷号: 6, 期号: 1, 页码: 20
作者:
Cao, Yutao
;
Ai, Yue
;
Zhang, Xiaosheng
;
Zhang, Jinlong
;
Long, Xianlei
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/21