Diterpenoid constituents of Euphorbia macrorrhiza
文献类型：期刊论文
| 作者 | Gao, J (Gao, Jie); Chen, QB (Chen, Qi-Bin); Liu, YQ (Liu, Yong-Qiang); Xin, XL (Xin, Xue-Lei); Yili, A (Yili, Ablimiti); Aisa, HA (Aisa, Haji Akber)
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 122期号:2页码:246-253 |
| 关键词 | Euphorbia macrorrhiza CA Mey Euphorbiaceae Diterpenoids Cytotoxicity Multidrug resistance reversal activity |
| 通讯作者 | Aisa, HA |
| 英文摘要 | Ten diterpenoids, named macrorilone A-B, macroripremyrsinone A, macrorilathyrone A-B, macrorieuphorone A-B and macroricasbalone A-C, together with ten known diterpenoids, jatrophalone, sikkimenoids A-D, jatrophodione A, latilagascenes F, jolkinol B, 15 beta-O-benzoyl-5 alpha-hydroxyisolathyrol and jatrophalactone were isolated from the whole plant of Euphorbia macrorrhiza C.A. Mey. These diterpenoids belong to six skeleton-types, including jatropholane, premyrsinane, lathyrane, euphoractin, casbene and rhamnofolane diterpenoids. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HRESIMS spectroscopic data. The absolute configurations of macrorilone B, macroripremyrsinone A and macrorilathyrone A were established by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Several of the isolated compounds exhibited weak cytotoxicity against the KB and KBv200 cell lines with IC50 values ranging from 21.19 to 47.87 mu M. Some also showed multidrug resistance (MDR) reversal activity, among which macrorilathyrone B exhibited a remarkable inhibitory effect on P-gp-mediated drug exclusion. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000369460200027 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/4342]  |
| 专题 | 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, J ,Chen, QB ,Liu, YQ ,et al. Diterpenoid constituents of Euphorbia macrorrhiza[J]. PHYTOCHEMISTRY,2016,122(2):246-253. |
| APA | Gao, J ,Chen, QB ,Liu, YQ ,Xin, XL ,Yili, A ,&Aisa, HA .(2016).Diterpenoid constituents of Euphorbia macrorrhiza.PHYTOCHEMISTRY,122(2),246-253. |
| MLA | Gao, J ,et al."Diterpenoid constituents of Euphorbia macrorrhiza".PHYTOCHEMISTRY 122.2(2016):246-253. |
入库方式： OAI收割
来源：新疆理化技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。