Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness
文献类型：期刊论文
| 作者 | Cheng WL(程玮璐); Li H(李慧); Zheng XF(郑雄飞) ; Chen, Lei; Cheng F(程凤); He JM(贺金梅); Liu, Ke; Cai, Panpan; Wang XF(王晓峰); Huang YD(黄玉东)
|
| 刊名 | PHYSICAL CHEMISTRY CHEMICAL PHYSICS
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:42页码:29183-29191 |
| ISSN号 | 1463-9076 |
| 产权排序 | 3 |
| 通讯作者 | 王晓峰 ; 黄玉东 |
| 中文摘要 | Collagen, one of the most biocompatible materials in nature, is widely used in wound healing and organ repair. However, the limited mechanical strength and biological effectiveness of collagen restrain its application as a hemostasis and filling material in medicine. To overcome these limitations, ultraporous collagen/oxidized regenerated cellulose (Col/ORC) composites were prepared. The results showed that the Col-0.25% ORC composite had optimal wettability, porosity, and water absorption. An MTT assay proved that the Col and Col/ORC composites possessed no cytotoxicity in living cells. Evaluation of the hemostatic time in vivo and the amount of bleeding in two injury models revealed that the Col-0.25% ORC composite has the most outstanding biological effectiveness and could be biodegraded completely without any inflammatory reaction after 3 weeks. The SEM micrographs showed that the fasciculate ORC fibers were evenly dispersed into the reticulate structure of the Col sponge. The FT-IR spectra of the Col-ORC composites were completely different from that of neat ORC, but similar to Col spectra. Moreover, a possible hemostasis mechanism was discussed based on ELISA analysis, coagulation function, and physicochemical properties. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical ; Physics, Atomic, Molecular & Chemical |
| 研究领域[WOS] | Chemistry ; Physics |
| 关键词[WOS] | OXIDIZED REGENERATED CELLULOSE ; IONIC LIQUID ; WOUND REPAIR ; GELATIN ; SURFACE ; FIBERS ; AGENTS ; BLOOD ; DRUG ; FILM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000387024300019 |
| 源URL | [http://ir.sia.cn/handle/173321/19429]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 推荐引用方式 GB/T 7714 | Cheng WL,Li H,Zheng XF,et al. Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2016,18(42):29183-29191. |
| APA | Cheng WL.,Li H.,Zheng XF.,Chen, Lei.,Cheng F.,...&Huang YD.(2016).Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,18(42),29183-29191. |
| MLA | Cheng WL,et al."Processing, characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 18.42(2016):29183-29191. |
入库方式： OAI收割
来源：沈阳自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。