Poroelasticity of cell nuclei revealed through atomic force microscopy characterization
文献类型：期刊论文
| 作者 | Wei FN(魏发南); Lan, Fei; Liu B(刘斌); Liu LQ(刘连庆) ; Li GY(李广勇)
|
| 刊名 | Applied Physics Letters
 |
| 出版日期 | 2016 |
| 卷号 | 109期号:21页码:1-5 |
| ISSN号 | 0003-6951 |
| 产权排序 | 1 |
| 通讯作者 | 刘连庆 ; 李广勇 |
| 中文摘要 | With great potential in precision medical application, cell biomechanics is rising as a hot topic in biology. Cell nucleus, as the largest component within cell, not only contributes greatly to the cell's mechanical behavior, but also serves as the most vital component within cell. However, cell nucleus' mechanics is still far from unambiguous up to now. In this paper, we attempted to characterize and evaluate the mechanical property of isolated cell nuclei using Atomic Force Microscopy with a tipless probe. As indicated from typical indentation, changing loading rate and stress relaxation experiment results, cell nuclei showed significant dynamically mechanical property, i.e., time-dependent mechanics. Furthermore, through theoretical analysis, finite element simulation and stress relaxation experiment, the nature of nucleus' mechanics was better described by poroelasticity, rather than viscoelasticity. Therefore, the essence of nucleus' mechanics was clarified to be poroelastic through a sophisticated analysis. Finally, we estimated the poroelastic parameters for nuclei of two types of cells through a combination of experimental data and finite element simulation. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Physics, Applied |
| 研究领域[WOS] | Physics |
| 关键词[WOS] | POWER-LAW RHEOLOGY ; MECHANICAL-PROPERTIES ; VISCOELASTIC PROPERTIES ; DEFORMATION ; INDENTATION ; NANOSCALE |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000388834200031 |
| 源URL | [http://ir.sia.cn/handle/173321/19477]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 推荐引用方式 GB/T 7714 | Wei FN,Lan, Fei,Liu B,et al. Poroelasticity of cell nuclei revealed through atomic force microscopy characterization[J]. Applied Physics Letters,2016,109(21):1-5. |
| APA | Wei FN,Lan, Fei,Liu B,Liu LQ,&Li GY.(2016).Poroelasticity of cell nuclei revealed through atomic force microscopy characterization.Applied Physics Letters,109(21),1-5. |
| MLA | Wei FN,et al."Poroelasticity of cell nuclei revealed through atomic force microscopy characterization".Applied Physics Letters 109.21(2016):1-5. |
入库方式： OAI收割
来源：沈阳自动化研究所
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