New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk
文献类型：期刊论文
| 作者 | Li, Y (Li, Yan); Yili, A (Yili, Abulimiti) ; Li, J (Li, Jun); Muhamat, A (Muhamat, Aziz); Aisa, HA (Aisa, Haji Akber)
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2016 |
| 卷号 | 26期号:8页码:1983-1987 |
| 关键词 | Fritillaria pallidiflora Isosteroidal alkaloid Yibeinones A-D Tracheal relaxant effect |
| 英文摘要 | Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3 beta-D-glucoside (5), imperialine (6), imperialine beta-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA(2) values of 6.19 +/- 0.02 and 8.41 +/- 0.10, and EC50 values of 0.65 +/- 0.02 mu mol L-1 and 4.40 +/- 0.90 nmol L-1, respectively. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000372509000024 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/4668]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Y ,Yili, A ,Li, J ,et al. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(8):1983-1987. |
| APA | Li, Y ,Yili, A ,Li, J ,Muhamat, A ,&Aisa, HA .(2016).New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(8),1983-1987. |
| MLA | Li, Y ,et al."New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.8(2016):1983-1987. |
入库方式： OAI收割
来源：新疆理化技术研究所
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