Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration
文献类型：期刊论文
| 作者 | Ren FF1,4; Shi Q1; Chen YB2; Jiang A1,5; Ip YT3; Jiang HQ1; Jiang J[*]1,2 |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:9页码:1133-1146 |
| 关键词 | Myc ISC Hpo JAK-STAT EGFR regeneration |
| 通讯作者 | Jin.Jiang@utsouthwestern.edu |
| 合作状况 | 其它 |
| 英文摘要 | Intestinal stem cells (ISCs) in the Drosophila adult midgut are essential for maintaining tissue homeostasis, and their proliferation and differentiation speed up in order to meet the demand for replenishing the lost cells in response to injury. Several signaling pathways including JAK-STAT, EGFR and Hippo (Hpo) pathways have been implicated in damage-induced ISC proliferation, but the mechanisms that integrate these pathways have remained elusive. Here, we demonstrate that the Drosophila homolog of the oncoprotein Myc (dMyc) functions downstream of these signaling pathways to mediate their effects on ISC proliferation. dMyc expression in precursor cells is stimulated in response to tissue damage, and dMyc is essential for accelerated ISC proliferation and midgut regeneration. We show that tissue damage caused by dextran sulfate sodium feeding stimulates dMyc expression via the Hpo pathway, whereas bleomycin feeding activates dMyc through the JAK-STAT and EGFR pathways. We provide evidence that dMyc expression is transcriptionally upregulated by multiple signaling pathways, which is required for optimal ISC proliferation in response to tissue damage. We have also obtained evidence that tissue damage can upregulate dMyc expression post-transcriptionally. Finally, we show that a basal level of dMyc expression is required for ISC maintenance, proliferation and lineage differentiation during normal tissue homeostasis. |
| 收录类别 | SCI |
| 资助信息 | JJ is a Eu- gene McDermott Endowed Scholar in Biomedical Science at the UTSW and is supported by grants from CPRIT (RP100561), NIH (GM061269 and GM06745) and Welch foundation (I-1603). YC is supported by grants from the National Natural Science Founda- tion of China (31271579), National Key Basic Research Program of China (2013CB910900) and American Heart Association post- doctoral fellowship (10POST3640046). YTI is supported by NIH (R01DK83450), is a member of the UMass DERC (DK32520) and a member of the Guangdong Innovative Research Team Program (201001Y0104789252). |
| 语种 | 英语 |
| WOS记录号 | WOS:000323930200011 |
| 公开日期 | 2013-09-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7688]  |
| 专题 | 昆明动物研究所_肿瘤信号转导 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China 3.Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA 4.Current address: Wuxi AppTec, Wuxi, Jiangsu 214092, Chin 5.Current address: Department of Biochemistry and Cell Biology, Rice Uni- versity, Houston, TX 77251, USA |
| 推荐引用方式 GB/T 7714 | Ren FF,Shi Q,Chen YB,et al. Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration[J]. CELL RESEARCH,2013,23(9):1133-1146. |
| APA | Ren FF.,Shi Q.,Chen YB.,Jiang A.,Ip YT.,...&Jiang J[*].(2013).Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration.CELL RESEARCH,23(9),1133-1146. |
| MLA | Ren FF,et al."Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration".CELL RESEARCH 23.9(2013):1133-1146. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。