Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities
文献类型：期刊论文
| 作者 | Yang, Jun1; Liu, Xiong-Wei1; Wang, Dan-Dan1; Tian, Min-Yi1; Han, Shuo-Nan1; Feng, Ting-Ting1; Liu, Xiong-Li1; Mei, Ren-Qiang2; Zhou, Ying1 |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2016-12-29 |
| 卷号 | 72期号:52页码:8523-8536 |
| 关键词 | Five-membered carbocyclic spirooxindoles One-pot multicomponent synthesis Knoevenagel condensation/Michael/cyclization Aminomethylation Antitumor activity |
| 英文摘要 | Described herein is a facile and efficient methodology for diversity-oriented one-pot multicomponent synthesis of 3-aminomethyl quaternary carbon oxindole fused five-membered carbocyclic spirooxindoles 5 via knoevenagel condensation/Michael/cyclization and then aminomethylation reaction. A wide variety of products with varying degrees of substitution around it, were obtained smoothly with high efficiency (up to overall yield 73% and >20:1 diastereoselectivity). In particular, their biological activities against these three cell lines 1(562, A549 and PC-3 have been evaluated. These results suggested that most of 3-aminomethyl quaternary carbon oxindole fused five-membered carbocyclic spirooxindoles 5 showed equipotent or more potent than the positive control of Cisplatin (up to 3.4 times). (C) 2016 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | REGIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION ; BAYLIS-HILLMAN CARBONATES ; HIGHLY ENANTIOSELECTIVE SYNTHESIS ; AZOMETHINE YLIDE CYCLOADDITION ; SPIRO-PYRIDO-PYRROLIZINES ; ALPHA-AMINO-ACIDS ; STEREOSELECTIVE-SYNTHESIS ; ASYMMETRIC-SYNTHESIS ; FACILE SYNTHESIS ; 3+2 ANNULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000390505000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/33788]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Guizhou Univ, Guizhou Engn Ctr Innovat Tradit Chinese Med & Eth, Guiyang 550025, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jun,Liu, Xiong-Wei,Wang, Dan-Dan,et al. Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities[J]. TETRAHEDRON,2016,72(52):8523-8536. |
| APA | Yang, Jun.,Liu, Xiong-Wei.,Wang, Dan-Dan.,Tian, Min-Yi.,Han, Shuo-Nan.,...&Zhou, Ying.(2016).Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities.TETRAHEDRON,72(52),8523-8536. |
| MLA | Yang, Jun,et al."Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities".TETRAHEDRON 72.52(2016):8523-8536. |
入库方式： OAI收割
来源：昆明植物研究所
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