Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity
文献类型：期刊论文
| 作者 | Chen, QB (Chen, Qi-Bin); Xin, XL (Xin, Xue-Lei); Aisa, HA (Aisa, Haji Akber); Aisa, HA
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| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:3页码:168-171 |
| 关键词 | Alkaloids Pyrrolo-isoquinoline alkaloids Glycosylated pyrrolidine alkaloids Nigella glandulifera Anti-PTP1B activity |
| 通讯作者 | Aisa, HA |
| 英文摘要 | Two new alkaloids, nigellisoquinomine (1) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine (2) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, agrocybenine (3) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one (4), were isolated from the seeds of Nigella glandulifera Freyn. Their structures were identified by extensive NMR and HR-ESIMS analysis. Compound 1 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 3.65 +/- 0.08 mu M. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000397455800032 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/4786]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 通讯作者 | Aisa, HA |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, PR, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, QB ,Xin, XL ,Aisa, HA ,et al. Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity[J]. PHYTOCHEMISTRY LETTERS,2017,19(3):168-171. |
| APA | Chen, QB ,Xin, XL ,Aisa, HA ,&Aisa, HA.(2017).Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity.PHYTOCHEMISTRY LETTERS,19(3),168-171. |
| MLA | Chen, QB ,et al."Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity".PHYTOCHEMISTRY LETTERS 19.3(2017):168-171. |
入库方式： OAI收割
来源：新疆理化技术研究所
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