Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components
文献类型：期刊论文
| 作者 | Edirs, S (Edirs, Salamet); Turak, A (Turak, Ablajan); Numonov, S (Numonov, Sodik); Xin, XL (Xin, Xuelei) ; Aisa, HA (Aisa, Haji Akber)
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| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 出版日期 | 2017 |
| 卷号 | 2017期号:5 |
| 通讯作者 | Xin, XL ; Aisa, HA |
| 英文摘要 | By using extraction yield, total polyphenolic content, antidiabetic activities (PTP-1B and alpha-glycosidase), and antioxidant activity (ABTS and DPPH) as indicated markers, the extraction conditions of the prescription Kursi Wufarikun Ziyabit (KWZ) were optimized by response surface methodology (RSM). Independent variables were ethanol concentration, extraction temperature, solid-to-solvent ratio, and extraction time. The result of RSM analysis showed that the four variables investigated have a significant effect (p < 0.05) for Y-1, Y-2, Y-3, Y-4, and Y-5 with R-2 value of 0.9120, 0.9793, 0.9076, 0.9125, and 0.9709, respectively. Optimal conditions for the highest extraction yield of 39.28%, PTP-1B inhibition rate of 86.21%, alpha-glycosidase enzymes inhibition rate of 96.56%, and ABTS inhibition rate of 77.38% were derived at ethanol concentration 50.11%, extraction temperature 72.06 degrees C, solid-to-solvent ratio 1:22.73 g/mL, and extraction time 2.93 h. On the basis of total polyphenol content of 48.44% in this optimal condition, the quantitative analysis of effective part of KWZ was characterized via UPLC method, 12 main components were identified by standard compounds, and all of them have shown good regression within the test ranges and the total content of them was 11.18%. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000401358200001 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/4802]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 推荐引用方式 GB/T 7714 | Edirs, S ,Turak, A ,Numonov, S ,et al. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017,2017(5). |
| APA | Edirs, S ,Turak, A ,Numonov, S ,Xin, XL ,&Aisa, HA .(2017).Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017(5). |
| MLA | Edirs, S ,et al."Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017.5(2017). |
入库方式： OAI收割
来源：新疆理化技术研究所
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