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Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

文献类型：期刊论文

作者Zhou, Hailong1,2,3,4; Wu, Huifeng1; Liao, Chunyang1; Diao, Xiaoping2; Zhen, Jiping2; Chen, Linlin1; Xue, Qinzhao1
刊名TOXICOLOGY MECHANISMS AND METHODS
出版日期2010-07-01
卷号20期号:6页码:279-286
关键词Persistent Organic Pollutants Ahr Pathway Toxicology Mechanism Fish
ISSN号1537-6524
产权排序[Zhou, Hailong; Wu, Huifeng; Liao, Chunyang; Chen, Linlin; Xue, Qinzhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhou, Hailong; Diao, Xiaoping; Zhen, Jiping] Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
通讯作者Xue, QZ, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
文献子类Review
英文摘要With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.; With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
学科主题Toxicology
URL标识查看原文
WOS关键词ARYL-HYDROCARBON RECEPTOR ; HEAT-SHOCK-PROTEIN ; NUCLEAR-LOCALIZATION SIGNAL ; POLYCYCLIC AROMATIC-HYDROCARBONS ; X-ASSOCIATED PROTEIN-2 ; ZEBRAFISH DANIO-RERIO ; CO-CHAPERONE P23 ; DIOXIN RECEPTOR ; DNA-BINDING ; NUCLEOCYTOPLASMIC TRANSPORT
WOS研究方向Toxicology
语种英语
WOS记录号WOS:000280402000001
资助机构Chinese Academy of Sciences [KZCX2-YW-Q07-05, KZCX2-YW-Q07-04]; Yantai municipal Science and technology development program [2007323]; Science and technology bureau of Yantai city [2009164]; Natural Science Foundation of Hainan Province [309010]; Education Department of Hainan Province [Hj2009-21]
公开日期2011-07-14
源URL[http://ir.yic.ac.cn/handle/133337/3802]  
专题烟台海岸带研究所_污染过程与控制实验室
烟台海岸带研究所_中科院烟台海岸带研究所知识产出
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Hailong,Wu, Huifeng,Liao, Chunyang,et al. Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(6):279-286.
APA Zhou, Hailong.,Wu, Huifeng.,Liao, Chunyang.,Diao, Xiaoping.,Zhen, Jiping.,...&Xue, Qinzhao.(2010).Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.TOXICOLOGY MECHANISMS AND METHODS,20(6),279-286.
MLA Zhou, Hailong,et al."Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway".TOXICOLOGY MECHANISMS AND METHODS 20.6(2010):279-286.

入库方式： OAI收割

来源：烟台海岸带研究所

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