Dynamical modeling and analysis of viscoelastic properties of single cells
文献类型：期刊论文
| 作者 | Liu B(刘斌); Liu LQ(刘连庆) ; Wang YC(王越超); Wang WX(王文学); Wang B(王博)
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| 刊名 | Micromachines
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| 出版日期 | 2017 |
| 卷号 | 8期号:6页码:1-11 |
| 关键词 | dynamical modeling mechanical properties principal component analysis atomic force microscopy viscoelasticity |
| ISSN号 | 2072-666X |
| 产权排序 | 1 |
| 通讯作者 | Wang WX(王文学) ; Liu LQ(刘连庆) |
| 中文摘要 | A single cell can be regarded as a complex network that contains thousands of overlapping signaling pathways. The traditional methods for describing the dynamics of this network are extremely complicated. The mechanical properties of a cell reflect the cytoskeletal structure and composition and are closely related to the cellular biological functions and physiological activities. Therefore, modeling the mechanical properties of single cells provides the basis for analyzing and controlling the cellular state. In this study, we developed a dynamical model with cellular viscoelasticity properties as the system parameters to describe the stress-relaxation phenomenon of a single cell indented by an atomic force microscope (AFM). The system order and parameters were identified and analyzed. Our results demonstrated that the parameters identified using this model represent the cellular mechanical elasticity and viscosity and can be used to classify cell types. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Instruments & Instrumentation |
| 研究领域[WOS] | Science & Technology - Other Topics ; Instruments & Instrumentation |
| 关键词[WOS] | ATOMIC-FORCE MICROSCOPY ; BREAST-CANCER ; NANOINDENTATION |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000404119100006 |
| 源URL | [http://ir.sia.cn/handle/173321/20757]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 作者单位 | 1.University of Chinese Academy of Sciences, Beijing 100049, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China |
| 推荐引用方式 GB/T 7714 | Liu B,Liu LQ,Wang YC,et al. Dynamical modeling and analysis of viscoelastic properties of single cells[J]. Micromachines,2017,8(6):1-11. |
| APA | Liu B,Liu LQ,Wang YC,Wang WX,&Wang B.(2017).Dynamical modeling and analysis of viscoelastic properties of single cells.Micromachines,8(6),1-11. |
| MLA | Liu B,et al."Dynamical modeling and analysis of viscoelastic properties of single cells".Micromachines 8.6(2017):1-11. |
入库方式： OAI收割
来源：沈阳自动化研究所
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