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A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing
文献类型：期刊论文
| 作者 | Ma, Jianjie; Li, Xiangguang; Zhang, Mingjun; Li M(李密) ; Zhu, Hua; Li, Haichang; Xu, Zihui; Liu LQ(刘连庆)
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| 刊名 | ACS Applied Materials and Interfaces
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| 出版日期 | 2017 |
| 卷号 | 9期号:27页码:22160-22175 |
| 关键词 | alginate and gum arabic atomic force microscopy (AFM) bioinspired hydrogel drug release and delivery recombinant human MG53 protein (rhMG53) wound healing and scarring |
| ISSN号 | 1944-8244 |
| 产权排序 | 1 |
| 通讯作者 | Liu LQ(刘连庆) ; Ma, Jianjie ; Zhang, Mingjun |
| 中文摘要 | Biopolymeric hydrogels have drawn increasing research interest in biomaterials due to their tunable physical and chemical properties for both creating bioactive cellular microenvironment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bioinspired hydrogel to deliver mitsugumin 53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro-/nanomorphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking. On the basis of atomic force microscopy (AFM) force measurements, an optimal sticky hydrogel scaffold was obtained through orthogonal experimental design. Imaging and mechanical analysis showed the distinct correlation between structural morphology, adhesion characteristics, and mechanical properties of the Sundew-inspired hydrogel. Combined characterization and biochemistry techniques were utilized to uncover the underlying molecular composition involved in the interactions between hydrogel and protein. In vitro drug release experiments confirmed that the Sundew-inspired hydrogel had a biphasic-kinetics release, which can facilitate both fast delivery of MG53 for improving the reepithelization process of the wounds and sustained release of the protein for treating chronic wounds. In vivo experiments showed that the Sundew-inspired hydrogel encapsulating with rhMG53 could facilitate dermal wound healing in mouse model. Together, these studies confirmed that the Sundew-inspired hydrogel has both tunable micro-/nanostructures and physicochemical properties, which enable it as a delivery vehicle for chronic wounding healing. The research may provide a new way to develop biocompatible and tunable biomaterials for sustainable drug release to meet the needs of biological activities. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | CELL-MEMBRANE REPAIR ; HUMAN MG53 PROTEIN ; BIOMEDICAL APPLICATIONS ; MECHANICAL-PROPERTIES ; ADHESION PROPERTIES ; CANCER-CELLS ; STEM-CELLS ; DELIVERY ; INJURY ; TISSUE |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000405764700011 |
| 源URL | [http://ir.sia.cn/handle/173321/20806]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 作者单位 | 1.College of Animal Science, South China Agricultural University, Guangzhou, 510642, China 2.Dorothy M. Davis Heart and Lung Research Institute, Wexner Medical Center, Ohio State University, Columbus, OH, 43210, United States 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 4.Interdisciplinary Biophysics Graduate Program, Ohio State University, Columbus, OH, 43210, United States 5.Department of Surgery, Ohio State University, Columbus, OH, 43210, United States 6.Department of Biomedical Engineering, College of Engineering, Ohio State University, Columbus, OH, 43210, United States |
| 推荐引用方式 GB/T 7714 | Ma, Jianjie,Li, Xiangguang,Zhang, Mingjun,et al. A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing[J]. ACS Applied Materials and Interfaces,2017,9(27):22160-22175. |
| APA | Ma, Jianjie.,Li, Xiangguang.,Zhang, Mingjun.,Li M.,Zhu, Hua.,...&Liu LQ.(2017).A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing.ACS Applied Materials and Interfaces,9(27),22160-22175. |
| MLA | Ma, Jianjie,et al."A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing".ACS Applied Materials and Interfaces 9.27(2017):22160-22175. |
入库方式： OAI收割
来源：沈阳自动化研究所
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