Patterned microwell arrays for single-cell analysis & drug screening
文献类型：会议论文
| 作者 | Yang WG(杨文广); Liu LQ(刘连庆) ; Wang YC(王越超); Yu HB(于海波)
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| 出版日期 | 2017 |
| 会议名称 | 1st International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017 |
| 会议日期 | July 17-21, 2017 |
| 会议地点 | Montreal, Canada |
| 关键词 | micro-well arrays microfabrication single-cell drug screening |
| 页码 | 1-5 |
| 通讯作者 | Yu HB(于海波) ; Liu LQ(刘连庆) |
| 中文摘要 | Nowadays, cells are commonly used for predicting whether the drug compounds will be effective and safe in human. The response of cell groups was usually analyzed, instead of single cell. However, individual cells within the same population even shows various characteristics. Understanding this heterogeneity is critical to studying how effective therapies will be in the clinic. Therefore, highly efficient analysis of single cell has become important for cellular biologists for both fundamental and drug screening. Recently, several methods including microscopy, laser capture microdissection, flow cytometry and microfluidic techniques have been developed for study the single cell. However, miniaturization, simplification and multifunction are still main challenges for the development of single cell analytical tool. In this paper, we have presented an easy-to-use and versatile method to fabricate various microwells for single cell analysis. Cells could grow into arbitrary shapes with constrained microwells. The microwells were able to be removed to investigate cell shapes effect on growth via our method. Furthermore, 3D multicellular spheroids which can be used for dug screening were formed based on micro-wells arrays. |
| 收录类别 | EI |
| 产权排序 | 1 |
| 会议录 | International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017 - Proceedings
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| 会议录出版者 | IEEE |
| 会议录出版地 | New York |
| 语种 | 英语 |
| ISBN号 | 978-1-5386-0346-8 |
| 源URL | [http://ir.sia.cn/handle/173321/21072]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 作者单位 | 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China 2.University of Chinese Academy of Sciences, Beijing, 100049, China |
| 推荐引用方式 GB/T 7714 | Yang WG,Liu LQ,Wang YC,et al. Patterned microwell arrays for single-cell analysis & drug screening[C]. 见:1st International Conference on Manipulation, Automation and Robotics at Small Scales, MARSS 2017. Montreal, Canada. July 17-21, 2017. |
入库方式： OAI收割
来源：沈阳自动化研究所
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