The Effect of Loading Rate on the Measurement of Cellular Viscoelasticity Properties with Atomic Force Microscopy
文献类型：会议论文
| 作者 | Wang B(王博); Wang WX(王文学) ; Liu LQ(刘连庆); Liu B(刘斌); Wang YC(王越超)
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| 出版日期 | 2017 |
| 会议名称 | 2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) |
| 会议日期 | Augest 7-11, 2017 |
| 会议地点 | Shanghai, CHINA |
| 关键词 | single cell dynamic model mechanical properties loading rate viscoelasticity atomic force microscope |
| 页码 | 246-249 |
| 通讯作者 | Wang WX(王文学) ; Liu LQ(刘连庆) |
| 中文摘要 | Organisms are composed by cells, and the cells can also reflect the physiology of creatures. The composition of a single cell and its cytoskeletal structure can be reflected by the mechanical properties of the cell. The cellular mechanical properties are correlated to the biological functions of the cell and its physiological activities. Therefore, establishing the mathematical model for the mechanical properties of single cells could provide the foundation for analyzing and regulating the physiological state of cells. In our previous work, we established a dynamical mathematical model with the viscose and elastic properties of single cells as the system parameters of the cellular system. The mathematical model can characterize the stress-relaxation phenomenon of a single cell, which is caused by an atomic force microscope (AFM). However, in this model, the effect of the loading rate of the AFM cantilever was neglected and all the stress-relaxation curves needed to be measured at a constant loading rate, in case that different loading rates would cause errors in the stress-relaxation curves. In this study, we discussed the effect of the loading rate on the measurement of cellular viscoelasticity properties with AFM. We clearly illustrated that the cellular stress-relaxation curves won't be effected by the loading rate of AFM when the loading rate is higher than a threshold. The stress-relaxation curves with the loading rate which is higher than the threshold can be used to extract viscoelasticity parameters more accurately. |
| 收录类别 | EI ; CPCI（ISTP） |
| 产权排序 | 1 |
| 会议主办者 | Natl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg |
| 会议录 | 2017 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
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| 会议录出版者 | IEEE |
| 会议录出版地 | NEW YORK |
| 语种 | 英语 |
| ISSN号 | 2373-5422 |
| ISBN号 | 978-1-5386-1081-7 |
| WOS记录号 | WOS:000426927300052 |
| 源URL | [http://ir.sia.cn/handle/173321/21653]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 作者单位 | 1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences 2.University of Chinese Academy of Sciences, Beijing |
| 推荐引用方式 GB/T 7714 | Wang B,Wang WX,Liu LQ,et al. The Effect of Loading Rate on the Measurement of Cellular Viscoelasticity Properties with Atomic Force Microscopy[C]. 见:2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). Shanghai, CHINA. Augest 7-11, 2017. |
入库方式： OAI收割
来源：沈阳自动化研究所
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