Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip
文献类型：期刊论文
| 作者 | Wang FF(王飞飞); Li WJ(李文荣); Liu LQ(刘连庆); Wang YC(王越超); Lee, Gwo-Bin; Liu N(刘娜); Yu HB(于海波); Li P(李盼); Liu JG(刘金国) ; Shen XH(沈昕慧)
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| 刊名 | Biomaterials Science
 |
| 出版日期 | 2018 |
| 卷号 | 6期号:6页码:1371-1378 |
| ISSN号 | 2047-4830 |
| 产权排序 | 1 |
| 通讯作者 | Liu LQ(刘连庆) ; Li WJ(李文荣) |
| 中文摘要 | The development of microengineered hydrogels co-cultured with cells in vitro could advance in vivo bio-systems in both structural complexity and functional hierarchy, which holds great promise for applications in regenerative tissues or organs, drug discovery and screening, and bio-sensors or bio-actuators. Traditional hydrogel microfabrication technologies such as ultraviolet (UV) laser or multiphoton laser stereolithography and three-dimensional (3D) printing systems have advanced the development of 3D hydrogel micro-structures but need either expensive and complex equipment, or harsh material selection with limited photoinitiators. Herein, we propose a simple and flexible hydrogel microfabrication method based on a ubiquitous visible-light projection system combined with a custom-designed photosensitive microfluidic chip, to rapidly (typically several to tens of seconds) fabricate various two-dimensional (2D) hydrogel patterns and 3D hydrogel constructs. A theoretical layer-by-layer model that involves continuous polymerizing-delaminating-polymerizing cycles is presented to explain the polymerization and structural formation mechanism of hydrogels. A large area of hydrogel patterns was efficiently fabricated without the usage of costly laser systems or photoinitiators, i.e., a stereoscopic mesh-like hydrogel network with intersecting hydrogel micro-belts was fabricated via a series of dynamic-changing digital light projections. The pores and gaps of the hydrogel network are tunable, which facilitates the supply of nutrients and discharge of waste in the construction of 3D thick bio-models. Cell co-culture experiments showed the effective regulation of cell spreading by hydrogel scaffolds fabricated by the new method presented here. This visible light enabled hydrogel microfabrication method may provide new prospects for designing cell-based units for advanced biomedical studies, e.g., for 3D bio-models or bio-actuators in the future. |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000433604100007 |
| 源URL | [http://ir.sia.cn/handle/173321/21869]  |
| 专题 | 沈阳自动化研究所_空间自动化技术研究室 |
| 通讯作者 | Liu JG(刘金国) |
| 作者单位 | 1.Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong 2.Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan 3.94305, United States 4.Department of Chemistry, Stanford University, Stanford CA 5.School of Mechatronics Engineering and Automation, Shanghai University, Shanghai 200072, China 6.University of Chinese Academy of Sciences, Beijing 100000, China 7.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China |
| 推荐引用方式 GB/T 7714 | Wang FF,Li WJ,Liu LQ,et al. Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip[J]. Biomaterials Science,2018,6(6):1371-1378. |
| APA | Wang FF.,Li WJ.,Liu LQ.,Wang YC.,Lee, Gwo-Bin.,...&Shen XH.(2018).Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip.Biomaterials Science,6(6),1371-1378. |
| MLA | Wang FF,et al."Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip".Biomaterials Science 6.6(2018):1371-1378. |
入库方式： OAI收割
来源：沈阳自动化研究所
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