Research on rat's pulmonary acute injury induced by lunar soil simulant
文献类型：期刊论文
| 作者 | Bo, Wei; Wang, Xuguang; Wan, Bing; Sun Y(孙燕); Liu JG(刘金国) ; Xiao, Chunling; Guo, Li; Zheng, Yongchun
|
| 刊名 | Journal of the Chinese Medical Association
 |
| 出版日期 | 2018 |
| 卷号 | 81期号:2页码:133-140 |
| 关键词 | Acute injury Lunar soil simulant Lung Rat |
| ISSN号 | 1726-4901 |
| 产权排序 | 1 |
| 通讯作者 | Sun Y(孙燕) |
| 中文摘要 | Background: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with histopathologic observations. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, General & Internal |
| 研究领域[WOS] | General & Internal Medicine |
| 关键词[WOS] | BRONCHOALVEOLAR LAVAGE ; OXIDATIVE STRESS ; IN-VITRO ; ACTIVATION ; SURFACE ; MICE ; INFLAMMATION ; PARTICLES ; TOXICITY ; FUTURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000425706600008 |
| 源URL | [http://ir.sia.cn/handle/173321/21365]  |
| 专题 | 沈阳自动化研究所_空间自动化技术研究室 |
| 作者单位 | 1.Laboratory Medicine of Central Hospital Affiliated to Shenyang Medical College, Shenyang, China 2.National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China 4.Shenyang Medical College, Shenyang, China |
| 推荐引用方式 GB/T 7714 | Bo, Wei,Wang, Xuguang,Wan, Bing,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. Journal of the Chinese Medical Association,2018,81(2):133-140. |
| APA | Bo, Wei.,Wang, Xuguang.,Wan, Bing.,Sun Y.,Liu JG.,...&Zheng, Yongchun.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.Journal of the Chinese Medical Association,81(2),133-140. |
| MLA | Bo, Wei,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".Journal of the Chinese Medical Association 81.2(2018):133-140. |
入库方式： OAI收割
来源：沈阳自动化研究所
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