Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury
文献类型：期刊论文
| 作者 | Kong, Yidi1; Hu, Jiasen1; Zhang, Xiaoping3; Sun Y(孙燕)1,2; Liu JG(刘金国)2; Zhang XY(张心宇) ; Cao H(曹晖); Wang ED(王恩德); Yang GY(杨光宇)
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2018 |
| 卷号 | 14期号:6页码:766-772 |
| ISSN号 | 1811-7775 |
| 关键词 | Lunar soil simulant acute injury inflammation immune response oxidative stress reaction |
| 通讯作者 | Sun Y(孙燕) |
| 产权排序 | 1 |
| 中文摘要 | Background and Objective: Lunar dust is a kind of fine particles exists on the surface of the moon and it has become one of the most important challenges in future space missions. Lunar dust is toxic but the understanding of lunar dust toxicity is very poor. The aim of this study was to investigate the acute lung injury induced by lunar soil simulant and the mechanism of toxicity. Materials and Methods: Wistar rats were randomly divided into four groups including saline control group (tracheal perfusion in a 1 mL volume), two Chinese Academy of Sciences-1(CAS-1) lunar soil simulant groups (tracheal perfusion with 7 and 0.7 mg, respectively in a 1 mL volume) and PM2.5 group (tracheal perfusion with 0.7 mg in a 1 mL volume). The levels of tumor necrosis factor alpha, interleukin 6, immunoglobulin A and immunoglobulin G in the bronchoalveolar lavage fluid were examined and the changes of malondialdehyde, glutathione peroxidase and superoxide dismutase in the lung tissue were later measured after 4 and 24 h. Results:The determination of the cytokines, immunoglobulin and the oxidative stress index in lung tissue showed that the significant immune and oxidative stress response in the respiratory system were caused by lunar soil simulant and the immune and oxidative stress response promoted each other, resulting in toxic effect on pulmonary parenchymal cells and membrane of rats. Conclusion: The overall results showed that the immune response and oxidative stress reaction induced by lunar soil simulant were significant in the respiratory system. They promote each other, so as to cause the toxic effects on the lung parenchyma cells and membrane tissues of rats. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000438908200003 |
| 源URL | [http://ir.sia.cn/handle/173321/22366]  |
| 专题 | 沈阳自动化研究所_光电信息技术研究室 |
| 作者单位 | 1.Shenyang Medical College, 110034 Shenyang, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 110016 Shenyang, China 3.Lunar and Planetary Science Laboratory, Macau University of Science and Technology, 519020 Macau, China |
| 推荐引用方式 GB/T 7714 | Kong, Yidi,Hu, Jiasen,Zhang, Xiaoping,et al. Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2018,14(6):766-772. |
| APA | Kong, Yidi.,Hu, Jiasen.,Zhang, Xiaoping.,Sun Y.,Liu JG.,...&杨光宇.(2018).Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury.INTERNATIONAL JOURNAL OF PHARMACOLOGY,14(6),766-772. |
| MLA | Kong, Yidi,et al."Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury".INTERNATIONAL JOURNAL OF PHARMACOLOGY 14.6(2018):766-772. |
入库方式： OAI收割
来源：沈阳自动化研究所
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