A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.
文献类型：期刊论文
| 作者 | Liu, XX (Liu, Xixi)[ 1,2,3 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ] ; Xin, XL (Xin, Xuelei)[ 1,2 ]
|
| 刊名 | Natural product research
 |
| 出版日期 | 2019 |
| 卷号 | 33期号:4页码:472-476 |
| 关键词 | Nigella sativa var hispidula fatty acid ester phenolic compounds anti-PTP1B activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2017.1396594 |
| 英文摘要 | A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38±0.14muM in vitro. |
| WOS记录号 | WOS:000465153400003 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/5485]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 通讯作者 | Xin, XL (Xin, Xuelei)[ 1,2 ] |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China 3.Univ Chinese Acad Sci, Beijing, PR, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, XX ,Aisa, HA ,Xin, XL . A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.[J]. Natural product research,2019,33(4):472-476. |
| APA | Liu, XX ,Aisa, HA ,&Xin, XL .(2019).A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity..Natural product research,33(4),472-476. |
| MLA | Liu, XX ,et al."A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.".Natural product research 33.4(2019):472-476. |
入库方式： OAI收割
来源：新疆理化技术研究所
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。