A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals
文献类型：期刊论文
| 作者 | Jin, Sen3,4; Peng, Jie1,2; Yuan, Jing1,2; He, Xiaobin3,4; Gong, Hui1,2; Xu, Fuqiang1,2,3,4; Xu, Tonghui1,2; Li, Haohong1,2; Cui, Yuting1,2; Lv, Guanghui1,2 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017-11-14 |
| 卷号 | 21期号:7页码:1770-1782 |
| DOI | 10.1016/j.celrep.2017.10.062 |
| 文献子类 | Article |
| 英文摘要 | Aversive stimuli can impact motivation and support associative learning as reinforcers. However, the neural circuitry underlying the processing of aversive reinforcers has not been elucidated. Here, we report that a subpopulation of central amygdala (CeA) GABAergic neurons expressing protein kinase C-delta (PKC-delta+) displays robust responses to aversive stimuli during negative reinforcement learning. Importantly, projections from PKC-delta+ neurons of the CeA to the substantia innominata (SI) could bi-directionally modulate negative reinforcement learning. Moreover, consistent with the idea that SI-projecting PKC-delta+ neurons of the CeA encode aversive information, optogenetic activation of this pathway produces conditioned place aversion, a behavior prevented by simultaneous ablating of SI glutamatergic neurons. Taken together, our data define a cell-type-specific neural circuitry modulating associative learning by encoding aversive reinforcement signals. |
| WOS关键词 | BASAL FOREBRAIN ; CONDITIONED FEAR ; INHIBITORY CIRCUITS ; RABIES VIRUS ; PASSIVE FEAR ; NEURONS ; PROJECTIONS ; PREDICTION ; BEHAVIORS ; NUCLEUS |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000415073200007 |
| 资助机构 | National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Natural Science Foundation of China(91432107 ; National Natural Science Foundation of China(91432107 ; Science Fund for Creative Research Group of China(61421064) ; Science Fund for Creative Research Group of China(61421064) ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; 31671105) ; 31671105) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Natural Science Foundation of China(91432107 ; National Natural Science Foundation of China(91432107 ; Science Fund for Creative Research Group of China(61421064) ; Science Fund for Creative Research Group of China(61421064) ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; 31671105) ; 31671105) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11593]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Engn Sci, MoE Key Lab Biomed Photon, Collaborat Innovat Ctr Biomed Engn, Wuhan 430074, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Hubei, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, Ctr Brain Sci,Key Lab Magnet Resonance Biol Syst, Wuhan, Hubei, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Sen,Peng, Jie,Yuan, Jing,et al. A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals[J]. CELL REPORTS,2017,21(7):1770-1782. |
| APA | Jin, Sen.,Peng, Jie.,Yuan, Jing.,He, Xiaobin.,Gong, Hui.,...&Lv, Guanghui.(2017).A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals.CELL REPORTS,21(7),1770-1782. |
| MLA | Jin, Sen,et al."A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals".CELL REPORTS 21.7(2017):1770-1782. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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