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A corticopontine circuit for initiation of urination

文献类型：期刊论文

作者Chen, Xiaowei2,6,7; Yan, Junan8; Xu, Xiaohong4; Jia, Hongbo1; Gong, Hui2,5; Xu, Fuqiang2,3; Li, Tong6,7; Zhang, Wen4; He, Wenjing6,7; Zhang, Jianxiong6,7
刊名NATURE NEUROSCIENCE
出版日期2018-11-01
卷号21期号:11页码:1541-+
ISSN号1097-6256
DOI10.1038/s41593-018-0256-4
英文摘要Urination (also called micturition) is thought to be regulated by a neural network that is distributed in both subcortical and cortical regions. Previously, urination-related neurons have been identified in subcortical structures such as the pontine micturition center (also known as Barrington's nucleus). However, the origin of the descending cortical pathway and how it interfaces with this subcortical circuit to permit voluntary initiation of urination remain elusive. Here we identified a small cluster of layer 5 neurons in the primary motor cortex whose activities tightly correlate with the onset of urination in freely behaving mice and increase dramatically during territorial marking. Optogenetically activating these neurons elicits contraction of the bladder and initiates urination, through their projections to the pontine micturition center, while silencing or ablating them impairs urination and causes retention of urine. Together these results reveal a novel cortical component upstream of the pontine micturition center that is critically involved in urination.
WOS关键词LOWER URINARY-TRACT ; NEURONS IN-VIVO ; NEURAL-CONTROL ; AUDITORY-CORTEX ; BLADDER CONTROL ; MICTURITION ; NETWORK ; BRAIN ; REFLEX ; CORD
资助项目1000 Talents Program for Young Scholars ; National Natural Science Foundation of China[81671106] ; National Natural Science Foundation of China[81771175] ; National Natural Science Foundation of China[31700933] ; National Basic Research Program of China ("973 Program")[2015CB759500] ; National Key Research and Development Program of China[2018YFA0109600] ; Science Fund for Creative Research Group of China[61721092] ; ULabor RD Program[2017ULab0001]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000448319500008
出版者NATURE PUBLISHING GROUP
资助机构1000 Talents Program for Young Scholars ; National Natural Science Foundation of China ; National Basic Research Program of China ("973 Program") ; National Key Research and Development Program of China ; Science Fund for Creative Research Group of China ; ULabor RD Program ; 1000 Talents Program for Young Scholars ; National Natural Science Foundation of China ; National Basic Research Program of China ("973 Program") ; National Key Research and Development Program of China ; Science Fund for Creative Research Group of China ; ULabor RD Program ; 1000 Talents Program for Young Scholars ; National Natural Science Foundation of China ; National Basic Research Program of China ("973 Program") ; National Key Research and Development Program of China ; Science Fund for Creative Research Group of China ; ULabor RD Program ; 1000 Talents Program for Young Scholars ; National Natural Science Foundation of China ; National Basic Research Program of China ("973 Program") ; National Key Research and Development Program of China ; Science Fund for Creative Research Group of China ; ULabor RD Program
源URL[http://ir.wipm.ac.cn/handle/112942/13193]  
专题中国科学院武汉物理与数学研究所
通讯作者Chen, Xiaowei; Yan, Junan; Xu, Xiaohong
作者单位1.Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Brain Res Instrument Innovat Ctr, Suzhou, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Phys & Math, CAS Ctr Excellence Brain Sci, Wuhan, Hubei, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci,State Key Lab Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
5.Huazhong Univ Sci & Technol, Sch Engn Sci, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect,MoE Key Lab Biomed Photo, Wuhan, Hubei, Peoples R China
6.Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China
7.Third Mil Med Univ, Brain Res Ctr, Chongqing, Peoples R China
8.Third Mil Med Univ, Southwest Hosp, Dept Urol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xiaowei,Yan, Junan,Xu, Xiaohong,et al. A corticopontine circuit for initiation of urination[J]. NATURE NEUROSCIENCE,2018,21(11):1541-+.
APA Chen, Xiaowei.,Yan, Junan.,Xu, Xiaohong.,Jia, Hongbo.,Gong, Hui.,...&Yao, Jiwei.(2018).A corticopontine circuit for initiation of urination.NATURE NEUROSCIENCE,21(11),1541-+.
MLA Chen, Xiaowei,et al."A corticopontine circuit for initiation of urination".NATURE NEUROSCIENCE 21.11(2018):1541-+.

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