Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency
文献类型：期刊论文
| 作者 | Liu, Nianqing; Zu, Aijun; Liang, Dongchun; Zhang, Zhiyong; Guo, Gang; Chai, Zhifang |
| 刊名 | Biological trace element research
 |
| 出版日期 | 2006-12-01 |
| 卷号 | 114期号:1-3页码:207-215 |
| 关键词 | Iodine deficiency Iodine excess Iodine level in thyroid 5 '-deiodinase Thyroid hormones |
| ISSN号 | 0163-4984 |
| 通讯作者 | Liu, nianqing() |
| 英文摘要 | The weanling wistar rats of iodine deficiency were divided into three groups for supplementation of different levels of iodine (iodine-excessive [ie], iodine-adequate [ia], and iodine-deficient [id]), with a control group (c). the iodine content in the thyroid was determined by epithermal neutron activation analysis. the activities of 5'-deiodinase and 5-deiodinase in the brains were assayed by determining the conversion ratios of t4 to t3 and rt3, respectively. the thyroid hormones levels in serum were also tested. the results indicated that the id group had a goiter containing a small amount of iodine, but the ie group had a slightly swollen thyroid with rich iodine; the concentration of iodine per unit mass of thyroid was lower in group ie than in groups ia and c. the highest 5'-deiodinase and lowest 5-deiodinase activities in group id and the lowest 5'-deiodinase activity in group ie were found. the iodine deficiency or excess resulted in a compensated hypothyroid state. the results suggest that the iodine status and the deiodinases activities would become normal for the rats of iodine deficiency if adequate iodine is supplemented soon after birth. meanwhile, it is also critical to avoid excessive intake of iodine to reduce the risk for overcorrecting. |
| WOS关键词 | IODOTHYRONINE DEIODINASE ; HYPOTHYROIDISM ; HYPERTHYROIDISM ; CONVERSION ; THYROXINE ; ENZYME |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000243400700022 |
| 出版者 | HUMANA PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175839 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Nianqing |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100049, Peoples R China 2.Tianjin Inst Endocrinol, Tianjin 300070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Nianqing,Zu, Aijun,Liang, Dongchun,et al. Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency[J]. Biological trace element research,2006,114(1-3):207-215. |
| APA | Liu, Nianqing,Zu, Aijun,Liang, Dongchun,Zhang, Zhiyong,Guo, Gang,&Chai, Zhifang.(2006).Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency.Biological trace element research,114(1-3),207-215. |
| MLA | Liu, Nianqing,et al."Effect of iodine supplement on iodine status and 5 '-deiodinase activity in the brain of neonatal rats with iodine deficiency".Biological trace element research 114.1-3(2006):207-215. |
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