Quantitative imaging of element spatial distribution in the brain section of a mouse model of alzheimer's disease using synchrotron radiation x-ray fluorescence analysis
文献类型：期刊论文
| 作者 | Wang, Hua-Jian1,2,3; Wang, Meng1,2; Wang, Bing1,2; Meng, Xiang-Yu4; Wang, Yun1,2,3; Li, Ming1,2,3; Feng, Wei-Yue1,2; Zhao, Yu-Liang1,2; Chai, Zhi-Fang1,2 |
| 刊名 | Journal of analytical atomic spectrometry
 |
| 出版日期 | 2010 |
| 卷号 | 25期号:3页码:328-333 |
| ISSN号 | 0267-9477 |
| DOI | 10.1039/b921201a |
| 通讯作者 | Wang, meng(wangmeng@ihep.ac.cn) |
| 英文摘要 | A method for quantitative imaging of trace elements in sections of bio-tissues using synchrotron radiation microbeam x-ray fluorescence (sr-mu xrf) analysis was developed. the compton scattering in the sr-mu xrf spectrum was utilized as an internal standard to compensate the differences in thickness and density of thin bio-tissue sections. the ratios of element sensitivities to compton scattering peak obtained from two matrix-matched standard reference materials were used for the calculation of the concentrations of metals in a brain section. the concentrations of ca, fe, cu and zn in the standard reference material (gbw 08551, pig liver) determined by this method were in good agreement with the certified values. the detection limits of ca, fe, cu and zn at 2 s detection were 1.15, 0.53, 0.21, and 0.20 mu g g(-1), respectively. the method has been successfully applied in accurate and precise imaging of the element variations in the brain section of a transgenic mouse model of alzheimer's disease. |
| WOS关键词 | PLASMA-MASS SPECTROMETRY ; BIOLOGICAL TISSUE ; AMYLOID-PEPTIDE ; COPPER ; METAL ; EXPOSURE ; PLAQUES ; RATS ; TOOL |
| WOS研究方向 | Chemistry ; Spectroscopy |
| WOS类目 | Chemistry, Analytical ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000274961600009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2175965 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Meng |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hua-Jian,Wang, Meng,Wang, Bing,et al. Quantitative imaging of element spatial distribution in the brain section of a mouse model of alzheimer's disease using synchrotron radiation x-ray fluorescence analysis[J]. Journal of analytical atomic spectrometry,2010,25(3):328-333. |
| APA | Wang, Hua-Jian.,Wang, Meng.,Wang, Bing.,Meng, Xiang-Yu.,Wang, Yun.,...&Chai, Zhi-Fang.(2010).Quantitative imaging of element spatial distribution in the brain section of a mouse model of alzheimer's disease using synchrotron radiation x-ray fluorescence analysis.Journal of analytical atomic spectrometry,25(3),328-333. |
| MLA | Wang, Hua-Jian,et al."Quantitative imaging of element spatial distribution in the brain section of a mouse model of alzheimer's disease using synchrotron radiation x-ray fluorescence analysis".Journal of analytical atomic spectrometry 25.3(2010):328-333. |
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来源：高能物理研究所
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