Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment
文献类型：期刊论文
| 作者 | Lin, Yao-Xin1,2; Wang, Yi1,2; Qiao, Sheng-Lin1,2; An, Hong-Wei1,2; Zhang, Ruo-Xin1; Qiao, Zeng-Ying1; Rajapaksha, R. P. Y. J.1; Wang, Lei1; Wang, Hao1 |
| 刊名 | Small
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 12期号:21页码:2921-2931 |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201503709 |
| 通讯作者 | Wang, hao(wanghao@nanoctr.cn) |
| 英文摘要 | In drug delivery systems, ph-sensitive polymers are commonly used as drug carriers, and significant efforts have been devoted to the aspects of controlled delivery and release of drugs. however, few studies address the possible autophagic effects on cells. here, for the first time, using a fluorescent autophagy-reporting cell line, this study evaluates the autophagy-induced capabilities of four types of ph-sensitive polymeric nanoparticles (nps) with different physical properties, including size, surface modification, and ph-sensitivity. based on experimental results, this study concludes that ph-sensitivity is one of the most important factors in autophagy induction. in addition, this study finds that variation of concentration of nps could cause different autophagic effect, i.e., low concentration of nps induces autophagy in an mtor-dependent manner, but high dose of nps leads to autophagic cell death. identification of this tunable autophagic effect offers a novel strategy for enhancing therapeutic effect in cancer therapy through modulation of autophagy. |
| WOS关键词 | INTRACELLULAR DRUG-DELIVERY ; ORTHO ESTER GROUPS ; CELL-DEATH ; POLY(BETA-AMINO ESTER)S ; OXIDATIVE STRESS ; ANTICANCER DRUG ; CANCER-THERAPY ; OLIGO(ETHYLENE GLYCOL) ; GOLD NANOPARTICLES ; COPOLYMER MICELLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000378425000014 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176496 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Hao |
| 作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing, Peoples R China 2.UCAS, 19A Yuquan Rd, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Yao-Xin,Wang, Yi,Qiao, Sheng-Lin,et al. Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment[J]. Small,2016,12(21):2921-2931. |
| APA | Lin, Yao-Xin.,Wang, Yi.,Qiao, Sheng-Lin.,An, Hong-Wei.,Zhang, Ruo-Xin.,...&Wang, Hao.(2016).Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment.Small,12(21),2921-2931. |
| MLA | Lin, Yao-Xin,et al."Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment".Small 12.21(2016):2921-2931. |
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来源：高能物理研究所
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