Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression
文献类型：期刊论文
| 作者 | Lei, Yifeng1; Hamada, Yoh2; Li, Jun1; Cong, Liman2; Wang, Nuoxin1; Li, Ying1; Zheng, Wenfu1; Jiang, Xingyu1 |
| 刊名 | Journal of controlled release
 |
| 出版日期 | 2016-06-28 |
| 卷号 | 232页码:131-142 |
| 关键词 | Ferritin nanoparticles Drug delivery Pancreatic cancer Nervous microenvironment |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2016.03.023 |
| 通讯作者 | Zheng, wenfu(zhengwf@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Pancreatic cancer is a lethal malignancy whose progression is highly dependent on the nervous microenvironment. this study develops neural drug-loaded ferritin nanoparticles (ft nps) to regulate the nervous microenvironment, in order to control the pancreatic cancer progression. the drug-loaded ft nps can target pancreatic tumors via passive targeting of epr effects of tumors and active targeting via transferrin receptor 1 (tfr1) binding on cancer cells, with a triggered drug release in acidic tumor environment. two drugs, one activates neural activity (carbachol), the other impairs neural activity (atropine), are encapsulated into the ft nps to form two kinds of nano drugs, nano-cab nps and nano-ato nps, respectively. the activation of the nervous microenvironment by nano-cab nps significantly promotes the pancreatic tumor progression, whereas the blockage of neural niche by nano-ato nps remarkably impairs the neurogenesis in tumors and the progression of pancreatic cancer. the ft-based nanoparticles thus comprise an effective and safe route of delivery of neural drugs for novel anti-cancer therapy. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | AUTONOMIC NERVOUS-SYSTEM ; PERINEURAL INVASION ; DUCTAL ADENOCARCINOMA ; MUSCARINIC RECEPTORS ; TRANSFERRIN RECEPTOR ; GROWTH-FACTOR ; H-FERRITIN ; CARCINOMA ; CELLS ; EXPRESSION |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000377401000014 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2176512 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Tohoku Univ, Grad Sch Med, Dept Nanomed Sci, Sendai, Miyagi 9808575, Japan |
| 推荐引用方式 GB/T 7714 | Lei, Yifeng,Hamada, Yoh,Li, Jun,et al. Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression[J]. Journal of controlled release,2016,232:131-142. |
| APA | Lei, Yifeng.,Hamada, Yoh.,Li, Jun.,Cong, Liman.,Wang, Nuoxin.,...&Jiang, Xingyu.(2016).Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression.Journal of controlled release,232,131-142. |
| MLA | Lei, Yifeng,et al."Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression".Journal of controlled release 232(2016):131-142. |
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来源：高能物理研究所
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