中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of app/ps1 transgenic mice

文献类型:期刊论文

作者Liang, Shengxiang1,2,3,4; Huang, Jia2; Liu, Weilin2; Jin, Hao2; Li, Long2; Zhang, Xiufeng2; Nie, Binbin3,4,5; Lin, Ruhui2; Tao, Jing2; Zhao, Shujun1
刊名Behavioural brain research
出版日期2017-09-29
卷号335页码:26-31
关键词Alzheimer's disease Neurochemical metabolism Hippocampus N-acetylaspartate Magnetic resonance spectroscopy
ISSN号0166-4328
DOI10.1016/j.bbr.2017.08.005
通讯作者Zhao, shujun(zhaosj@zzu.edu.cn) ; Shan, baoci(shanbc@ihep.ac.cn) ; Chen, lidian(cld@fjtcm.edu.cn)
英文摘要Alzheimer's disease (ad) is characterized by neuropathological changes and progressive cognitive decline, which is associated with the volume loss and neurochemical alterations. however, the specific neurochemical alterations in cerebral regions that contribute to cognitive decline still remain unknown. in the present study, we measured cerebral morphological and neurochemical alterations using structural magnetic resonance imaging (mri) and proton magnetic resonance spectroscopy (h-1-mrs) in an ad model of app/ps1 transgenic mice. voxel-based morphometry (vbm) analysis indicated atrophy of the hippocampus, motor cortex, striatum, amygdaloid body, septal area, bed nucleus of the stria terminalis and accumbens nucleus in app/ps1 transgenic mice. furthermore, the hippocampus was selected as a region of interest (roi) to explore neurochemical metabolism. the results showed that the ratios of n-acetylaspartate/creatine (naa/cr) and glutamate/creatine (glu/cr) were reduced, while myo-inositol/creatine (min/cr) was increased in app/ps1 transgenic mice compared to the wild type mice and accompanied by a decline in learning and memory. taken together, the present study suggests that hippocampal atrophy and neurochemical changes in naa, glu and min may play a causative role in the cognitive decline associated with ad.
WOS关键词MILD COGNITIVE IMPAIRMENT ; ALZHEIMERS-DISEASE PATIENTS ; GLUTAMATE LEVELS ; BRAIN ; DEMENTIA ; MYOINOSITOL ; H-1-MRS ; DIAGNOSIS ; MRS
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
语种英语
WOS记录号WOS:000412034100004
出版者ELSEVIER SCIENCE BV
URI标识http://www.irgrid.ac.cn/handle/1471x/2177104
专题高能物理研究所
通讯作者Zhao, Shujun; Shan, Baoci; Chen, Lidian
作者单位1.Zhengzhou Univ, Coll Phys Sci & Technol, Zhengzhou 450001, Henan, Peoples R China
2.Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou 350122, Fujian, Peoples R China
3.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China
4.Beijing Engn Res Ctr Radiog Tech & Equipment, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Liang, Shengxiang,Huang, Jia,Liu, Weilin,et al. Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of app/ps1 transgenic mice[J]. Behavioural brain research,2017,335:26-31.
APA Liang, Shengxiang.,Huang, Jia.,Liu, Weilin.,Jin, Hao.,Li, Long.,...&Chen, Lidian.(2017).Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of app/ps1 transgenic mice.Behavioural brain research,335,26-31.
MLA Liang, Shengxiang,et al."Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of app/ps1 transgenic mice".Behavioural brain research 335(2017):26-31.

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