Contrast enhancement method of transmission electron microscopy in visualization of polymeric micelles by fluoride addition and staining
文献类型：期刊论文
| 作者 | Weng, Yu-Hua1,2,3,4; Che, Jing1,2,3; Ma, Xiao-Wei2,3,4; Guo, Hong-Bo2,3,4; Xue, Xiang-Dong2,3,4; Chen, Shi-Zhu2,3,4; Zhang, Xu2,3,4; Zhang, Ting-Bin2,3,4; Li, Chan2,3,4; Xu, Jing2,3,4 |
| 刊名 | Journal of biomedical nanotechnology
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 13期号:5页码:534-543 |
| 关键词 | Transmission electron microscopy Polymeric micelles Contrast enhancement Fluorine contrast medium |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2017.2375 |
| 通讯作者 | Hu, zhong-bo(huzq@ucas.ac.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | In this study, we focused on improving the tem image contrast of polymeric micelles by applying novel staining media during the tem sample preparation process. for the first time, two contrast enhancement methods for polymeric micelles tem visualization have been established. one strategy is to apply a new staining reagent containing flutamide (ftm) during tem sample preparation, and the other strategy is to pre-mix ftm with polymeric micelles solution before negativestaining procedure. both of the two strategies can significantly improve tem image contrast. techniques used in these methods are time-saving and useful for tem microscopy of polymeric micelles, and have potential in identification of many other soft nanomaterials, which may greatly facilitate the application of these materials in fields of nanotechnology, structural chemistry, and biomedical research. |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000404379600006 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177331 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Zhong-Bo; Liang, Xing-Jie |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol China, Lab Controllable Nanopharmaceut, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Weng, Yu-Hua,Che, Jing,Ma, Xiao-Wei,et al. Contrast enhancement method of transmission electron microscopy in visualization of polymeric micelles by fluoride addition and staining[J]. Journal of biomedical nanotechnology,2017,13(5):534-543. |
| APA | Weng, Yu-Hua.,Che, Jing.,Ma, Xiao-Wei.,Guo, Hong-Bo.,Xue, Xiang-Dong.,...&Liang, Xing-Jie.(2017).Contrast enhancement method of transmission electron microscopy in visualization of polymeric micelles by fluoride addition and staining.Journal of biomedical nanotechnology,13(5),534-543. |
| MLA | Weng, Yu-Hua,et al."Contrast enhancement method of transmission electron microscopy in visualization of polymeric micelles by fluoride addition and staining".Journal of biomedical nanotechnology 13.5(2017):534-543. |
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来源：高能物理研究所
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