Inhibition of lysozyme fibrillation by gold nanorods and nanoparticles
文献类型：期刊论文
| 作者 | Liang, Hongli1; Wang, Bing2; Wang, Hailong2; Yu, Miao2; Zheng, Lingna2; Wang, Meng2; Zhang, Aiping1; Feng, Weiyue2 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 18期号:5页码:3087-3094 |
| 关键词 | Gold nanorods and nanoparticles Lysozyme fibrillation Inhibition effects |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2018.14662 |
| 通讯作者 | Zhang, aiping() ; Feng, weiyue() |
| 英文摘要 | Amyloid fibrillation has been implicated in many neurodegenerations, dialysis-related amyloidosis, type ii diabetes and more than 30 other amyloid- related diseases. nanomaterials as potential inhibitors of amyloid fibrillation have attracted increasing interests. in the present study, the effects of gold nanorods (aunrs) and nanoparticles (aunps) on amyloid fibrillation were investigated using hen egg white lysozyme (hewl) as a model system. our results indicated that aunrs and aunps, especially aunrs, present significant inhibitory effects on hewl amyloid fibril formation during all the kinetic processes, from nucleation to elongation and equilibration stages. the stronger adsorption capacity of hewl on aunrs surface is the key mechanism of inhibition of hewl amyloid fibrillation. furthermore, aunrs lead to more stable alpha-helix conformation and hydrophobic microenvironment of aromatic side groups in hewl molecules, which facilitate the system to form small amorphous aggregates rather than oligomer, profibril or mature fibril. |
| WOS关键词 | AMYLOID-BETA OLIGOMERIZATION ; PROTEIN FIBRILLATION ; POLYMERIC NANOPARTICLES ; SIZE ; AGGREGATION ; NUCLEATION ; PATHWAYS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000426040800006 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177990 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhang, Aiping; Feng, Weiyue |
| 作者单位 | 1.Shanxi Med Univ, Dept Pharm, Taiyuan 030001, Shanxi, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Hongli,Wang, Bing,Wang, Hailong,et al. Inhibition of lysozyme fibrillation by gold nanorods and nanoparticles[J]. Journal of nanoscience and nanotechnology,2018,18(5):3087-3094. |
| APA | Liang, Hongli.,Wang, Bing.,Wang, Hailong.,Yu, Miao.,Zheng, Lingna.,...&Feng, Weiyue.(2018).Inhibition of lysozyme fibrillation by gold nanorods and nanoparticles.Journal of nanoscience and nanotechnology,18(5),3087-3094. |
| MLA | Liang, Hongli,et al."Inhibition of lysozyme fibrillation by gold nanorods and nanoparticles".Journal of nanoscience and nanotechnology 18.5(2018):3087-3094. |
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来源：高能物理研究所
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