Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional beclin 1
文献类型：期刊论文
| 作者 | Ding, Guo-Bin1,2; Sun, Junqing1,2; Wu, Gengfeng1,2; Li, Binchun1; Yang, Peng1,2; Li, Zhuoyu1,2,3; Nie, Guangjun4 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2018-02-14 |
| 卷号 | 10期号:6页码:5227-5239 |
| 关键词 | Functional beclin 1 Phlip Biological synthesis Autophagy induction Anticancer efficacy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b17454 |
| 通讯作者 | Ding, guo-bin(dinggb2012@sxu.edu.cn) ; Li, zhuoyu(lzy@sxu.edu.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | As a potent autophagy inducer, beclin 1 is essential for the initiation of autophagic cell death, and triggering extensive autophagy by targeted delivery of beclin 1 to tumors has enormous potential to inhibit tumor growth. yet, the therapeutic application of beclin 1 is hampered by its inability to internalize into cells and nonselective biodistribution in vivo. to tackle this challenge, we employed a novel beclin 1 delivery manner by constructing a functional protein (trx-phlip-beclin 1, tpb) composed of a thioredoxin (trx) tag, a ph low insertion peptide (phlip), and an evolutionarily conserved motif of beclin 1. this protein could effectively transport beclin 1 to breast and ovarian cancer cell lines under weakly acidic conditions (ph 6.5), markedly inhibit tumor cell growth and proliferation, and induce obvious autophagy. furthermore, the in vivo antitumor efficacy of the functional beclin 1 against an skov3 xenograft tumor mouse model was tested via intravenous injection. tpb preferentially accumulated in tumors and exhibited a significantly higher tumor growth inhibition than the nontargeted beclin 1 control, whereas no overt side effects were observed. taken together, this study sheds light on the potential application of tpb as a highly efficient yet safe antitumor agent for cancer treatment. |
| WOS关键词 | POTENTIAL THERAPEUTIC TARGET ; CANCER-THERAPY ; ESCHERICHIA-COLI ; IN-VIVO ; PHLIP ; PEPTIDE ; CELLS ; TRANSLOCATION ; PROTEINS ; MICROENVIRONMENT |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000425572700011 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178004 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ding, Guo-Bin; Li, Zhuoyu; Nie, Guangjun |
| 作者单位 | 1.Shanxi Univ, Minist Educ, Key Lab Chem Biol & Mol Engn, Inst Biotechnol, Taiyuan 030006, Shanxi, Peoples R China 2.Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Shanxi, Peoples R China 3.Shanxi Univ, Sch Life Sci, Taiyuan 030006, Shanxi, Peoples R China 4.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Guo-Bin,Sun, Junqing,Wu, Gengfeng,et al. Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional beclin 1[J]. Acs applied materials & interfaces,2018,10(6):5227-5239. |
| APA | Ding, Guo-Bin.,Sun, Junqing.,Wu, Gengfeng.,Li, Binchun.,Yang, Peng.,...&Nie, Guangjun.(2018).Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional beclin 1.Acs applied materials & interfaces,10(6),5227-5239. |
| MLA | Ding, Guo-Bin,et al."Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional beclin 1".Acs applied materials & interfaces 10.6(2018):5227-5239. |
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