Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells
文献类型：期刊论文
| 作者 | Gao, Ming; Zhao, Beibei; Chen, Minjun; Liu, Yun; Xu, Ming; Wang, Zhe; Liu, Sijin; Zhang, Chengdong |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 130期号:0页码:14-27 |
| 关键词 | Silver Nanoparticles Lncrna Odrul Cell Death Erythroid Cells |
| 英文摘要 | The biosafety and biological effects of silver nanoparticles (AgNPs) on human health attract increasing concern. Although considerable studies have been performed to reveal the molecular mechanisms responsible for AgNP-induced effects, the current understanding mainly focuses on oxidative stress-associated signaling pathways activated by Ag particles and/or Ag ions. However, the molecular bases underlying the activation of these stress signaling pathways have not been thoroughly elucidated yet. In the current study, we aimed to shed light on the molecular bases of AgNP-induced effects on erythroid cells from the perspective of long noncoding RNAs. We identified a long-noncoding RNA molecule, ODRUL, which was substantially enhanced in K562 erythroid cells responding to AgNPs, coupled to accelerated cell death. Further, we uncovered oxidative stress-driven Nrf2 transcriptionally promoted ODRUL expression in K562 cells. Downstream of Nrf2-ODRUL activation by AgNPs, ODRUL was recognized to interact with PI4Ka protein to modulate the activities of its targets AKT and JNK. As a result, the Bcl-2 level was negatively regulated by PI4K-AKT/JNK signaling under AgNP-induced stress, leading to enhanced cell death. Together, our findings unearthed that Nrf2-mediated lncRNA ODRUL was indispensable for AgNP-induced toxicity in erythroid cells through regulation of AKT/JNK-Bcl-2 signaling dependent on a physical interaction with PI4Ka. Thus, this study would open a new path to depict the molecular bases of AgNP-induced effects on erythroid cells. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39372]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Ming,Zhao, Beibei,Chen, Minjun,et al. Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells[J]. BIOMATERIALS,2017,130(0):14-27. |
| APA | Gao, Ming.,Zhao, Beibei.,Chen, Minjun.,Liu, Yun.,Xu, Ming.,...&Zhang, Chengdong.(2017).Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.BIOMATERIALS,130(0),14-27. |
| MLA | Gao, Ming,et al."Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells".BIOMATERIALS 130.0(2017):14-27. |
入库方式： OAI收割
来源：生态环境研究中心
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