Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells
文献类型：期刊论文
| 作者 | Hu, Yu1; Li, Xiao-Nian2; Ma, Ze-Jin1; Puno, Pema-Tenzin2 ; Zhao, Yong1; Zhao, Yan1; Xiao, Ye-Zhi1; Zhang, Wei1; Liu, Jing-Ping1
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| 刊名 | MOLECULES
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 23期号:12页码:9 |
| ISSN号 | 1420-3049 |
| 关键词 | ent-kaurane-type diterpenoid derivatives antitumor synthesis |
| 英文摘要 | We have designed and synthesized 6 ent-Kaurane-type diterpenoid derivatives containing ,-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT assay. All the tested compounds exhibited comparable or higher activity than DDP and eriocalyxin B. Compounds 16, 17 and 18 are promising anti-tumor leads due to their cytotoxic potencies and higher selectivity, with SI values of 161.06, 47.80 and 128.20, respectively. |
| 资助项目 | National Natural Science Foundation of China[21462053] ; Science Foundation of Yunnan Province Office of Education[2014Z044] ; Program of the Undergraduate Innovation[2018059] |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China ; Science Foundation of Yunnan Province Office of Education ; Program of the Undergraduate Innovation |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64300]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Puno, Pema-Tenzin; Liu, Jing-Ping |
| 作者单位 | 1.Yunnan Normal Univ, Dept Chem, Kunming 650092, Yunnan, Peoples R China 2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Yu,Li, Xiao-Nian,Ma, Ze-Jin,et al. Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells[J]. MOLECULES,2018,23(12):9. |
| APA | Hu, Yu.,Li, Xiao-Nian.,Ma, Ze-Jin.,Puno, Pema-Tenzin.,Zhao, Yong.,...&Liu, Jing-Ping.(2018).Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells.MOLECULES,23(12),9. |
| MLA | Hu, Yu,et al."Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells".MOLECULES 23.12(2018):9. |
入库方式： OAI收割
来源：昆明植物研究所
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