Validation of a hrgc-ecni/lrms method to monitor short-chain chlorinated paraffins in human plasma
文献类型：期刊论文
| 作者 | Xu, Jiazhi1,2; Guo, Weijing3; Wei, Linhuan3; Gao, Yuan1; Zhang, Haijun1; Zhang, Yichi1; Sun, Ming3; Chen, Jiping1 |
| 刊名 | Journal of environmental sciences
 |
| 出版日期 | 2019 |
| 卷号 | 75页码:289-295 |
| 关键词 | Short-chain chlorinated paraffins Sample preparation Quantitative analysis Human plasma |
| ISSN号 | 1001-0742 |
| DOI | 10.1016/j.jes.2018.04.004 |
| 通讯作者 | Zhang, haijun(hjzhang@dicp.ac.cn) ; Chen, jiping(chenjp@dicp.ac.cn) |
| 英文摘要 | Short-chain chlorinated paraffins (sccps) are produced in high volume and have the high potential to pose a threat to human health. however, little information is available for sccp contamination in human blood/plasma/serum, mainly due to the difficulty of sample preparation and quantitative analysis. a method using high resolution gas chromatography coupled with electron capture negative ionization low resolution mass spectrometry (hrgc-ecni/lrms) was developed and validated to measure sccps in human plasma. the pretreatment process included protein denaturation and lipid elimination, liquid-liquid extraction with a mixture of n-hexane/dichloromethane (1: 1, v/v), and cleanup on a multilayer silica column. the blank controls, including procedural blank, vacuum blood collection tube blank, and instrumental blank, were the most pivotal points for the reliable analysis of sccps. the average value of procedural blanks was 9.0 ng/g; and the method detection limit (mdl), calculated as the sum of the average procedural blank value and 3 times of the standard deviation of the procedural blanks, was 12.6 ng/g plasma. the validated method was applied to measure the concentrations of the total sccps (sigma sccps) in 50 plasma samples from a general population. the measured plasma concentrations of ssccps ranged from |
| WOS关键词 | HUMAN EXPOSURE ; FOOD-WEB ; SCCPS ; INDUCTION ; BEHAVIOR ; CHINA ; MILK ; AIR |
| WOS研究方向 | Environmental Sciences & Ecology |
| WOS类目 | Environmental Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000459207900027 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372747 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Zhang, Haijun; Chen, Jiping |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Ctr Dis Control & Prevent, Dalian 116021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jiazhi,Guo, Weijing,Wei, Linhuan,et al. Validation of a hrgc-ecni/lrms method to monitor short-chain chlorinated paraffins in human plasma[J]. Journal of environmental sciences,2019,75:289-295. |
| APA | Xu, Jiazhi.,Guo, Weijing.,Wei, Linhuan.,Gao, Yuan.,Zhang, Haijun.,...&Chen, Jiping.(2019).Validation of a hrgc-ecni/lrms method to monitor short-chain chlorinated paraffins in human plasma.Journal of environmental sciences,75,289-295. |
| MLA | Xu, Jiazhi,et al."Validation of a hrgc-ecni/lrms method to monitor short-chain chlorinated paraffins in human plasma".Journal of environmental sciences 75(2019):289-295. |
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来源：大连化学物理研究所
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