Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam
文献类型：期刊论文
| 作者 | Liu, Yujie1; Fang, Yuan1,2; Liu, Yongxiang1,2; Wang, Zhaowei1,2; Lyu, Bao1; Hu, Yuanyang1; Zhou, Xi1,2 |
| 刊名 | Acta biochimica et biophysica sinica
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 51期号:2页码:131-138 |
| 关键词 | C3po Translin Trax Esi-2,1 Mir-bantam |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmy154 |
| 通讯作者 | Zhou, xi(zhouxi@wh.iov.cn) |
| 英文摘要 | Translin/trax complex, also named as c3po, is evolutionarily conserved and participates in diverse cellular processes in different organisms from yeast to human. c3po plays a critical role in the activation of rna-induced silencing complexes by promoting the unwinding and degradation of passenger strand of exogenous sirnas (exo-sirnas) in drosophila and human. moreover, human c3po (hc3po) has been found to broadly repress mirnas by degrading mirna precursors. however, the effect of drosophila melanogaster c3po (dmc3po) on endogenous sirna (endo-sirna) and mirna pathways remains unknown. here, we found that the loss of dmc3po promoted the accumulation of the passenger strand of esi-2.1 (hp-cg4068b), and resulted in the de-repression of the dna-damage-response gene mutagensensitive 308 (mus308), which is an endogenous slicer target of esi-2.1 in drosophila. moreover, we also found that depletion of dmc3po increased the accumulation of mir-bantam. taken together, our findings indicated that dmc3po not only involves in sirna pathway triggered by dsrna, but also regulates the abundance of certain endogenous small rnas in drosophila. |
| WOS关键词 | DISTINCT MECHANISMS ; ENDOGENOUS SIRNAS ; RNA INTERFERENCE ; TRANSLIN ; PROTEIN ; PATHWAY ; SUPPRESSION ; INHIBITION ; INFECTION ; CLEAVAGE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000462569900002 |
| 出版者 | OXFORD UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373166 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhou, Xi |
| 作者单位 | 1.Wuhan Univ, State Key Lab Virol, Coll Life Sci, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yujie,Fang, Yuan,Liu, Yongxiang,et al. Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam[J]. Acta biochimica et biophysica sinica,2019,51(2):131-138. |
| APA | Liu, Yujie.,Fang, Yuan.,Liu, Yongxiang.,Wang, Zhaowei.,Lyu, Bao.,...&Zhou, Xi.(2019).Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam.Acta biochimica et biophysica sinica,51(2),131-138. |
| MLA | Liu, Yujie,et al."Opposite effects of drosophila c3po on gene silencing mediated by esi-2.1 and mirna-bantam".Acta biochimica et biophysica sinica 51.2(2019):131-138. |
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来源：武汉病毒研究所
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