Upregulation of hbv transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor myrcludex b
文献类型：期刊论文
| 作者 | Zhao, Kaitao1,2; Liu, Shuhui1,2; Chen, Yingshan1,2; Yao, Yongxuan1,2; Zhou, Ming3; Yuan, Yifei1,2; Wang, Yun1; Pei, Rongjuan1; Chen, Jizheng1; Hu, Xue1 |
| 刊名 | Emerging microbes & infections
 |
| 出版日期 | 2018-11-21 |
| 卷号 | 7页码:14 |
| ISSN号 | 2222-1751 |
| DOI | 10.1038/s41426-018-0189-8 |
| 通讯作者 | Wu, chunchen(wucc@wh.iov.cn) ; Chen, xinwen(chenxw@wh.iov.cn) |
| 英文摘要 | Sodium taurocholate cotransporting polypeptide (ntcp) is a functional receptor for hepatitis b virus (hbv) entry. however, little is known regarding whether ntcp is involved in regulating the postentry steps of the hbv life cycle. here, we found that ntcp expression upregulated hbv transcription at the postentry step and that the ntcp-targeting entry inhibitor myrcludex b (myrb) effectively suppressed hbv transcription both in an hbv in vitro infection system and in mice hydrodynamically injected with an hbv expression plasmid. mechanistically, ntcp upregulated hbv transcription via farnesoid x receptor alpha (fxr alpha)-mediated activation of the hbv en2/core promoter at the postentry step in a manner that was dependent on the bile acid (ba)-transport function of ntcp, which was blocked by myrb. our findings uncover a novel role for ntcp in the hbv life cycle and provide a reference for the use of novel ntcp-targeting entry inhibitors to suppress hbv infection and replication. |
| WOS关键词 | HEPATITIS-D VIRUS ; NUCLEAR RECEPTOR ; MOLECULAR DETERMINANTS ; MOUSE MODEL ; BILE-SALTS ; INFECTION ; SIRT1 ; TRANSPORTERS ; REPLICATION ; PROTEIN |
| WOS研究方向 | Immunology ; Microbiology |
| WOS类目 | Immunology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000451243400003 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373221 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wu, Chunchen; Chen, Xinwen |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2,Shenzhen Xenotransplantat, State & Local Joint Canc Genome Clin Applicat Key, Shenzhen 518035, Peoples R China 4.Univ Hosp Essen, Inst Virol, D-45147 Essen, Germany |
| 推荐引用方式 GB/T 7714 | Zhao, Kaitao,Liu, Shuhui,Chen, Yingshan,et al. Upregulation of hbv transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor myrcludex b[J]. Emerging microbes & infections,2018,7:14. |
| APA | Zhao, Kaitao.,Liu, Shuhui.,Chen, Yingshan.,Yao, Yongxuan.,Zhou, Ming.,...&Chen, Xinwen.(2018).Upregulation of hbv transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor myrcludex b.Emerging microbes & infections,7,14. |
| MLA | Zhao, Kaitao,et al."Upregulation of hbv transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor myrcludex b".Emerging microbes & infections 7(2018):14. |
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来源：武汉病毒研究所
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