A distinct entorhinal cortex to hippocampal ca1 direct circuit for olfactory associative learning
文献类型：期刊论文
| 作者 | Li, Yiding1,2,3,4; Xu, Jiamin5; Liu, Yafeng6,7; Zhu, Jia1,4; Liu, Nan2,3; Zeng, Wenbo8; Huang, Ning9,10; Rasch, Malte J.2,3; Jiang, Haifei8; Gu, Xiang2,3 |
| 刊名 | Nature neuroscience
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 20期号:4页码:559-+ |
| ISSN号 | 1097-6256 |
| DOI | 10.1038/nn.4517 |
| 通讯作者 | Zhang, xiaohui(xhzhang@bnu.edu.cn) |
| 英文摘要 | Lateral and medial parts of entorhinal cortex (ec) convey nonspatial `what' and spatial `where' information, respectively, into hippocampal ca1, via both the indirect ec layer 2 -> hippocampal dentate gyrus.-> ca3 -> ca1 and the direct ec layer 3 -> ca1 paths. however, it remains elusive how the direct path transfers distinct information and contributes to hippocampal learning functions. here we report that lateral ec projection neurons selectively form direct excitatory synapses onto a subpopulation of morphologically complex, calbindin-expressing pyramidal cells (pcs) in the dorsal ca1 (dca1), while medial ec neurons uniformly innervate all dca1 pcs. optogenetically inactivating the distinct lateral ec-dca1 connections or the postsynaptic dca1 calbindin-expressing pc activity slows olfactory associative learning. moreover, optetrode recordings reveal that dca1 calbindin-expressing pcs develop more selective spiking responses to odor cues during learning. thus, our results identify a direct lateral ec. dca1 circuit that is required for olfactory associative learning. |
| WOS关键词 | PYRAMIDAL NEURONS ; ODOR-DISCRIMINATION ; GENE-EXPRESSION ; THETA-CELLS ; PLACE CELLS ; AREA CA1 ; MEMORY ; INTERNEURONS ; RAT ; DYNAMICS |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000397558800011 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373450 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhang, Xiaohui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 3.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Shanghai, Peoples R China 5.East China Normal Univ, Sch Life Sci, Minist Educ, Key Lab Brain Funct Genom, Shanghai, Peoples R China 6.Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan, Peoples R China 7.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Dept Biomed Engn, Wuhan, Peoples R China 8.Chinese Acad Sci, Wuhan Inst Virol, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Virol, Wuhan, Peoples R China 9.Peking Univ, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing, Peoples R China 10.Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yiding,Xu, Jiamin,Liu, Yafeng,et al. A distinct entorhinal cortex to hippocampal ca1 direct circuit for olfactory associative learning[J]. Nature neuroscience,2017,20(4):559-+. |
| APA | Li, Yiding.,Xu, Jiamin.,Liu, Yafeng.,Zhu, Jia.,Liu, Nan.,...&Zhang, Xiaohui.(2017).A distinct entorhinal cortex to hippocampal ca1 direct circuit for olfactory associative learning.Nature neuroscience,20(4),559-+. |
| MLA | Li, Yiding,et al."A distinct entorhinal cortex to hippocampal ca1 direct circuit for olfactory associative learning".Nature neuroscience 20.4(2017):559-+. |
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来源：武汉病毒研究所
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