The inhibition of h1n1 influenza virus-induced apoptosis by silver nanoparticles functionalized with zanamivir
文献类型：期刊论文
| 作者 | Lin, Zhengfang1; Li, Yinghua1; Guo, Min1; Xu, Tiantian1; Wang, Changbing1; Zhao, Mingqi1; Wang, Hanzhong2; Chen, Tianfeng3; Zhu, Bing1 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:2页码:742-750 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra25010f |
| 通讯作者 | Chen, tianfeng(tianfengchen2016@hotmail.com) ; Zhu, bing(zhubing2016@hotmail.com) |
| 英文摘要 | As one of the most effective drugs for influenza virus infection, clinical application of zanamivir is restricted with the emergence of resistant influenza virus. it is crucial to manufacture novel pharmaceuticals against influenza virus infection. in recent years silver nanoparticles (agnps) have attracted wide attention in the antiviral field. in this study, we demonstrated surface decoration of agnps using zanamivir (znv) with antiviral properties. agnps co-delivery of the zanamivir nanosystem was designed to reverse influenza virus resistance. in brief, zanamivir modified agnps (ag@znv) inhibited the neuraminidase activity of the h1n1 virus. moreover, cytopathic effect showed that ag@znv remarkably resisted h1n1 virus-induced apoptosis of mdck cells, involving dna fragmentation, chromatin condensation and caspase-3 activation. ag@znv effectively reduced the accumulation of reactive oxygen species (ros) induced by h1n1 virus and activation of both p38 and p53 signaling pathways. taken together, our study indicates that ag@znv is a novel promising pharmaceutical against h1n1 influenza virus infection. |
| WOS关键词 | SELENIUM NANOPARTICLES ; IN-VITRO ; EPITHELIAL-CELLS ; ROS ; VIVO ; OSELTAMIVIR ; RESISTANCE ; MUTATIONS ; INFECTION ; EMERGENCE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000393743000020 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373475 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Tianfeng; Zhu, Bing |
| 作者单位 | 1.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Ctr Lab, Guangzhou 510120, Guangdong, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 3.Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Zhengfang,Li, Yinghua,Guo, Min,et al. The inhibition of h1n1 influenza virus-induced apoptosis by silver nanoparticles functionalized with zanamivir[J]. Rsc advances,2017,7(2):742-750. |
| APA | Lin, Zhengfang.,Li, Yinghua.,Guo, Min.,Xu, Tiantian.,Wang, Changbing.,...&Zhu, Bing.(2017).The inhibition of h1n1 influenza virus-induced apoptosis by silver nanoparticles functionalized with zanamivir.Rsc advances,7(2),742-750. |
| MLA | Lin, Zhengfang,et al."The inhibition of h1n1 influenza virus-induced apoptosis by silver nanoparticles functionalized with zanamivir".Rsc advances 7.2(2017):742-750. |
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来源：武汉病毒研究所
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