Folate-conjugated polylactic acid-silica hybrid nanoparticles as degradable carriers for targeted drug delivery, on-demand release and simultaneous self-clearance
文献类型：期刊论文
| 作者 | Ma, Zhifang1,2; Li, Xiaolei3; Jia, Xiaodan1; Bai, Jing1; Jiang, Xiue1 |
| 刊名 | Chempluschem
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 81期号:7页码:652-659 |
| 关键词 | Cancer Drug delivery In vivo degradable nanocarriers On-demand drug release Silica nanoparticles |
| ISSN号 | 2192-6506 |
| DOI | 10.1002/cplu.201600100 |
| 通讯作者 | Jiang, xiue(jiangxiue@ciac.ac.cn) |
| 英文摘要 | Improving the therapeutic efficacy of cancer chemotherapy and reducing the side effects in patients are appealing goals but represent critical challenges. in this work, a novel sio2-based nanocarrier coated with polylactic acid and folate has been fabricated to destroy tumors invivo. folic acid promotes the targeted intracellular delivery of drug molecules to cancer cells overexpressing the folate receptor for improving the efficacy of the therapy. the polylactic acid layer prevents the premature leakage of drug until the polylactic acid is degraded as a response to low ph and enzymes; this mechanism is designed for sustained and on-demand drug release to prevent undesired side effects. escape of the drug molecules then triggers decomposition of the sio2 carrier, improving its elimination from the patient. the strategy of combining the engineering flexibility of inorganic nanocarriers with the stimuli-responsive biodegradability of organic molecules will offer new directions in on-demand and sustained drug release for chemotherapy. |
| WOS关键词 | RESPONSIVE CONTROLLED-RELEASE ; IN-VITRO ; URINARY-EXCRETION ; CANCER-THERAPY ; SYSTEM ; BIOCOMPATIBILITY ; BIODISTRIBUTION ; PARTICLES ; VIVO ; PLA |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000379956600009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374550 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jiang, Xiue |
| 作者单位 | 1.Changchun Inst Appl Chem, State Key Lab Elect Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Zhifang,Li, Xiaolei,Jia, Xiaodan,et al. Folate-conjugated polylactic acid-silica hybrid nanoparticles as degradable carriers for targeted drug delivery, on-demand release and simultaneous self-clearance[J]. Chempluschem,2016,81(7):652-659. |
| APA | Ma, Zhifang,Li, Xiaolei,Jia, Xiaodan,Bai, Jing,&Jiang, Xiue.(2016).Folate-conjugated polylactic acid-silica hybrid nanoparticles as degradable carriers for targeted drug delivery, on-demand release and simultaneous self-clearance.Chempluschem,81(7),652-659. |
| MLA | Ma, Zhifang,et al."Folate-conjugated polylactic acid-silica hybrid nanoparticles as degradable carriers for targeted drug delivery, on-demand release and simultaneous self-clearance".Chempluschem 81.7(2016):652-659. |
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来源：中国科学院大学
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