Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
文献类型：期刊论文
| 作者 | Chen, Zhuo1,2; Zhang, Yaxin1,2,3; Wang, Dong1,2,3; Li, Linsen4; Zhou, Shanyong1; Huang, Joy H.1; Chen, Jincan1; Hu, Ping1; Huang, Mingdong1,2 |
| 刊名 | Journal of biomedical optics
 |
| 出版日期 | 2016 |
| 卷号 | 21期号:1页码:7 |
| 关键词 | Photodynamic antimicrobial chemotherapy Zinc phthalocyanine Bacterial infection Skin Propionibacterium acnes Staphylococcus aureus |
| ISSN号 | 1083-3668 |
| DOI | 10.1117/1.jbo.21.1.018001 |
| 通讯作者 | Chen, zhuo(zchen@fjirsm.ac.cn) ; Huang, mingdong(mhuang@fjirsm.ac.cn) |
| 英文摘要 | Photodynamic antimicrobial chemotherapy (pact) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. we herein reported the pact effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine beta-carbonylphthalocyanine zinc (znpc-(lys)(5)). compared with its anionic znpc counterpart, znpc-(lys)(5) showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. meanwhile, znpc-(lys)(5) was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. this study provides new insight on the mechanisms of pact in bacterial skin infection. (c) 2016 society of photo-optical instrumentation engineers (spie) |
| WOS关键词 | STAPHYLOCOCCUS-AUREUS ; THERAPY ; PEPTIDES ; STRAINS ; AGENTS ; MODEL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000380036500029 |
| 出版者 | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374551 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Zhuo; Huang, Mingdong |
| 作者单位 | 1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, 155 West Yangqiao Rd, Fuzhou 350002, Fujian, Peoples R China 2.Chinese Acad Sci, Grad Univ, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Fujian Normal Univ, 1 Keji Rd, Fuzhou 350117, Fujian, Peoples R China 4.Shenyang Med Coll, 146 North Huanghe Main St, Shenyang 110034, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhuo,Zhang, Yaxin,Wang, Dong,et al. Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection[J]. Journal of biomedical optics,2016,21(1):7. |
| APA | Chen, Zhuo.,Zhang, Yaxin.,Wang, Dong.,Li, Linsen.,Zhou, Shanyong.,...&Huang, Mingdong.(2016).Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection.Journal of biomedical optics,21(1),7. |
| MLA | Chen, Zhuo,et al."Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection".Journal of biomedical optics 21.1(2016):7. |
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来源：中国科学院大学
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