Lnc-beta-catm elicits ezh2-dependent beta-catenin stabilization and sustains liver csc self-renewal
文献类型：期刊论文
| 作者 | Zhu, Pingping1,2; Wang, Yanying1; Huang, Guanling1,3; Ye, Buqing1; Liu, Benyu1,3; Wu, Jiayi1,3; Du, Ying1; He, Lei4; Fan, Zusen1,3 |
| 刊名 | Nature structural & molecular biology
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 23期号:7页码:631-639 |
| ISSN号 | 1545-9993 |
| DOI | 10.1038/nsmb.3235 |
| 通讯作者 | Fan, zusen(fanz@moon.ibp.ac.cn) |
| 英文摘要 | Liver cancer stem cells (cscs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (hcc); however, the molecular mechanisms underlying their self-renewal and differentiation remain largely unknown. through analysis of transcriptome microarray data, we identified a long noncoding rna (lncrna) called lnc-beta-catm, which is highly expressed in human hcc tumors and liver cscs. we found that lnc-beta-catm is required for self-renewal of liver cscs and tumor propagation in mice. lnc-beta-catm associates with beta-catenin and the methyltransferase ezh2, thereby promoting beta-catenin methylation. methylation suppresses the ubiquitination of beta-catenin and promotes its stability, thus leading to activation of wnt-beta-catenin signaling. accordingly, the expression of lnc-beta-catm, ezh2 and wnt-beta-catenin targets is positively correlated with cancer severity and prognosis of people with hcc. |
| WOS关键词 | CANCER STEM-CELLS ; TUMOR-INITIATING CELLS ; HEPATOCELLULAR-CARCINOMA ; WNT/BETA-CATENIN ; GENE-EXPRESSION ; THERAPEUTIC TARGET ; NONCODING RNAS ; EZH2 ; ACTIVATION ; METASTASIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000379368200004 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374677 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Fan, Zusen |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab Infect & Immun CAS, Beijing, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Pingping,Wang, Yanying,Huang, Guanling,et al. Lnc-beta-catm elicits ezh2-dependent beta-catenin stabilization and sustains liver csc self-renewal[J]. Nature structural & molecular biology,2016,23(7):631-639. |
| APA | Zhu, Pingping.,Wang, Yanying.,Huang, Guanling.,Ye, Buqing.,Liu, Benyu.,...&Fan, Zusen.(2016).Lnc-beta-catm elicits ezh2-dependent beta-catenin stabilization and sustains liver csc self-renewal.Nature structural & molecular biology,23(7),631-639. |
| MLA | Zhu, Pingping,et al."Lnc-beta-catm elicits ezh2-dependent beta-catenin stabilization and sustains liver csc self-renewal".Nature structural & molecular biology 23.7(2016):631-639. |
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来源：中国科学院大学
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