Molecular mechanism for stress-induced depression assessed by sequencing mirna and mrna in medial prefrontal cortex
文献类型：期刊论文
| 作者 | Ma, Ke1; Guo, Li2,3; Xu, Aiping4; Cui, Shan2; Wang, Jin-Hui1,2,3,4 |
| 刊名 | Plos one
 |
| 出版日期 | 2016-07-18 |
| 卷号 | 11期号:7页码:21 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0159093 |
| 通讯作者 | Wang, jin-hui(jhw@sun5.ibp.ac.cn) |
| 英文摘要 | Background major depression is a prevalent mood disorder. chronic stress is presumably main etiology that leads to the neuron and synapse atrophies in the limbic system. however, the intermediate molecules from stresses to neuronal atrophy remain elusive, which we have studied in the medial prefrontal cortices from depression mice. methods and results the mice were treated by the chronic unpredictable mild stress (cums) until they expressed depression-like behaviors confirmed by the tests of sucrose preference, forced swimming and y-maze. high-throughput sequencings of microrna and mrna in the medial prefrontal cortices were performed in cums-induced depression mice versus control mice to demonstrate the molecular profiles of major depression. in the medial prefrontal cortices of depression- like mice, the levels of mrnas that translated the proteins for the gabaergic synapses, dopaminergic synapses, myelination, synaptic vesicle cycle and neuronal growth were down-regulated. mirnas of regulating these mrnas are upregulated. conclusion the deteriorations of gabaergic and dopaminergic synapses as well as axonal growth are associated with cums-induced depression. |
| WOS关键词 | CHRONIC MILD STRESS ; MAGNETIC-RESONANCE SPECTROSCOPY ; GAMMA-AMINOBUTYRIC-ACID ; MAJOR DEPRESSION ; ANTIDEPRESSANT TREATMENT ; BIPOLAR DISORDER ; THERAPEUTIC TARGETS ; INHIBITORY DEFICITS ; MICRORNA EXPRESSION ; GABAERGIC NEURONS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000380169300035 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375112 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Jin-Hui |
| 作者单位 | 1.Qingdao Univ, Sch Pharm, Qingdao, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Univ Sci & Technol China, Coll Life Sci, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Ke,Guo, Li,Xu, Aiping,et al. Molecular mechanism for stress-induced depression assessed by sequencing mirna and mrna in medial prefrontal cortex[J]. Plos one,2016,11(7):21. |
| APA | Ma, Ke,Guo, Li,Xu, Aiping,Cui, Shan,&Wang, Jin-Hui.(2016).Molecular mechanism for stress-induced depression assessed by sequencing mirna and mrna in medial prefrontal cortex.Plos one,11(7),21. |
| MLA | Ma, Ke,et al."Molecular mechanism for stress-induced depression assessed by sequencing mirna and mrna in medial prefrontal cortex".Plos one 11.7(2016):21. |
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来源：中国科学院大学
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