Tlr ligand induced il-6 counter-regulates the anti-viral cd8(+) t cell response during an acute retrovirus infection
文献类型：期刊论文
| 作者 | Wu, Weimin1; Dietze, Kirsten K.1; Gibbert, Kathrin1; Lang, Karl S.2; Trilling, Mirko1; Yan, Huimin3; Wu, Jun4; Yang, Dongliang4; Lu, Mengji1; Roggendorf, Michael1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2015-05-21 |
| 卷号 | 5页码:14 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep10501 |
| 通讯作者 | Liu, jia(jia.liu@uni-due.de) |
| 英文摘要 | We have previously shown that toll-like receptor (tlr) agonists contribute to the control of viral infection by augmenting virus-specific cd8(+) t-cell responses. it is also well established that signaling by tlrs results in the production of pro-inflammatory cytokines such as interleukin 6 (il-6). however, how these pro-inflammatory cytokines influence the virus-specific cd8(+) t-cell response during the tlr agonist stimulation remained largely unknown. here, we investigated the role of tlr-induced il-6 in shaping virus-specific cd8(+) t-cell responses in the friend retrovirus (fv) mouse model. we show that the tlr agonist induced il-6 counter-regulates effector cd8(+) t-cell responses. il-6 potently inhibited activation and cytokine production of cd8(+) t cells in vitro. this effect was mediated by a direct stimulation of cd8(+) t cells by il-6, which induced upregulation of stat3 phosphorylation and socs3 and downregulated stat4 phosphorylation and t-bet. moreover, combining tlr stimulation and il-6 blockade during an acute fv infection resulted in enhanced virusspecific cd8(+) t-cell immunity and better control of viral replication. these results have implications for our understanding of the role of tlr induced pro-inflammatory cytokines in regulating effector t cell responses and for the development of therapeutic strategies to overcome t cell dysfunction in chronic viral infections. |
| WOS关键词 | TOLL-LIKE RECEPTOR ; INDUCED DEMYELINATING DISEASE ; MURINE LEUKEMIA-VIRUS ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; INTERLEUKIN-6 IL-6 ; VIRAL PERSISTENCE ; TH17 CELLS ; EFFECTOR ; INNATE |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000355508500001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375177 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Liu, Jia |
| 作者单位 | 1.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany 2.Univ Duisburg Essen, Univ Hosp Essen, Inst Immunol, Essen, Germany 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Infect Dis, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Weimin,Dietze, Kirsten K.,Gibbert, Kathrin,et al. Tlr ligand induced il-6 counter-regulates the anti-viral cd8(+) t cell response during an acute retrovirus infection[J]. Scientific reports,2015,5:14. |
| APA | Wu, Weimin.,Dietze, Kirsten K..,Gibbert, Kathrin.,Lang, Karl S..,Trilling, Mirko.,...&Liu, Jia.(2015).Tlr ligand induced il-6 counter-regulates the anti-viral cd8(+) t cell response during an acute retrovirus infection.Scientific reports,5,14. |
| MLA | Wu, Weimin,et al."Tlr ligand induced il-6 counter-regulates the anti-viral cd8(+) t cell response during an acute retrovirus infection".Scientific reports 5(2015):14. |
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来源：武汉病毒研究所
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