Nonleaching bacteria-responsive antibacterial surface based on a unique hierarchical
文献类型：期刊论文
| 作者 | Yan, Shunjie1,2; Shi, Hengchong1; Song, Lingjie1; Wang, Xianghong1,2; Liu, Lin1,2; Luan, Shifang1; Yang, Yuming1; Yin, Jinghua1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-09-21 |
| 卷号 | 8期号:37页码:24471-24481 |
| 关键词 | Cationic antimicrobial peptides Ph-responsive polymer Hierarchical architecture Bacteria-responsive Smart surfaces |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b08436 |
| 通讯作者 | Luan, shifang(sfluan@ciac.ac.cn) ; Yin, jinghua(yinjh@ciac.ac.cn) |
| 英文摘要 | Bacteria-responsive surfaces popularly exert their smart antibacterial activities by bacteria-triggered delivery of antibacterial agents; however, the antibacterial agents should be additionally reloaded for the renewal of these surfaces. herein a teversible, nonleaching bacteria-responsive antibacterial surface is prepared by taking advantage of a hierarchical polymer brush architecture. in this hierarchical surface, a ph-responsive poly(methacrylic acid) (pmaa), outer layer serves as an actuator modulating the surface behavior, on demand, while antimicrobial peptides (amp) are covalently immobilized on the inner layer. the pmaa hydration layer renders the hierarchical surface resistant to initial bacterial attachment and biocompatible under physiological conditions. when bacteria colonize the surface, the bacteria-triggered acidification allows the outermost pmaa chains to collapse, therefore exposing the underlying bactericidal amp to on-demand kill bacteria. in addition, the dead bacteria can be released once the pmaa chains resume, their hydrophilicity because of the environmental ph increase. the functionality of the nonleaching surface is reversible without additional reloading of the antibacterial agents. this approach provides a new methodology for the development of smart surfaces in a variety of practical biomedical applications. |
| WOS关键词 | TRANSFER RADICAL POLYMERIZATION ; INFECTION-RESISTANT SURFACES ; ANTIMICROBIAL PEPTIDE ; TRIGGERED RELEASE ; ACID) BRUSHES ; FILMS ; BIOMATERIALS ; ARCHITECTURE ; MECHANISM ; MEMBRANES |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000384033600024 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375743 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Luan, Shifang; Yin, Jinghua |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Shunjie,Shi, Hengchong,Song, Lingjie,et al. Nonleaching bacteria-responsive antibacterial surface based on a unique hierarchical[J]. Acs applied materials & interfaces,2016,8(37):24471-24481. |
| APA | Yan, Shunjie.,Shi, Hengchong.,Song, Lingjie.,Wang, Xianghong.,Liu, Lin.,...&Yin, Jinghua.(2016).Nonleaching bacteria-responsive antibacterial surface based on a unique hierarchical.Acs applied materials & interfaces,8(37),24471-24481. |
| MLA | Yan, Shunjie,et al."Nonleaching bacteria-responsive antibacterial surface based on a unique hierarchical".Acs applied materials & interfaces 8.37(2016):24471-24481. |
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来源：中国科学院大学
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