Mhbr, a lysr-type regulator involved in 3-hydroxybenzoate catabolism via gentisate in klebsiella pneumoniae m5a1
文献类型：期刊论文
| 作者 | Lin, Lu-Xia1,2; Liu, Hong1; Zhou, Ning-Yi1 |
| 刊名 | Microbiological research
 |
| 出版日期 | 2010 |
| 卷号 | 165期号:1页码:66-74 |
| 关键词 | 3-hydroxybenzoate Klebsiella pneumoniae m5a1 Lysr Mhbr Regulation |
| ISSN号 | 0944-5013 |
| DOI | 10.1016/j.micres.2008.08.001 |
| 通讯作者 | Zhou, ning-yi(n.zhou@pentium.whiov.ac.cn) |
| 英文摘要 | In klebsiella pneumoniae m5a1, mhbtdhim genes are involved in 3-hydroxybenzoate catabolism via the gentisate pathway. mhbr, which encodes a lysr-type transcriptional regulator, is divergently transcribed from the mhb structural genes. mhbr was found to be necessary for the expression of catabolic genes. transcriptional studies demonstrated that the mhb structural genes are transcribed as an operon. the promoters of mhbr and the mhb operon are sigma(70)-type and overlap with each other. 5' deletion analysis of the promoter transcription activity showed that a 233 bp fragment (position -144 to +89 according to the transcriptional start site of mhb operon) contained the element necessary for induction. beta-galactosidase activity assays and electrophoretic mobility shift assays showed that an inverted repeat sequence site 1 (ataacctccaggttat, position -70 to -55) within this fragment was critical for regulation. (c) 2008 elsevier gmbh. all. rights reserved. |
| WOS关键词 | ESCHERICHIA-COLI K-12 ; TRANSCRIPTIONAL ACTIVATOR ; NITROGEN-FIXATION ; STRAIN ADP1 ; OPERON ; GENE ; 6-HYDROXYLASE ; FAMILY ; DNA ; PURIFICATION |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000273894400008 |
| 出版者 | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375761 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhou, Ning-Yi |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Lu-Xia,Liu, Hong,Zhou, Ning-Yi. Mhbr, a lysr-type regulator involved in 3-hydroxybenzoate catabolism via gentisate in klebsiella pneumoniae m5a1[J]. Microbiological research,2010,165(1):66-74. |
| APA | Lin, Lu-Xia,Liu, Hong,&Zhou, Ning-Yi.(2010).Mhbr, a lysr-type regulator involved in 3-hydroxybenzoate catabolism via gentisate in klebsiella pneumoniae m5a1.Microbiological research,165(1),66-74. |
| MLA | Lin, Lu-Xia,et al."Mhbr, a lysr-type regulator involved in 3-hydroxybenzoate catabolism via gentisate in klebsiella pneumoniae m5a1".Microbiological research 165.1(2010):66-74. |
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来源：武汉病毒研究所
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