Modulation of a thermoregulated type vi secretion system by ahl-dependent quorum sensing in yersinia pseudotuberculosis
文献类型：期刊论文
| 作者 | Zhang, Weipeng1,2; Xu, Shengjuan1,2; Li, Jing1,2; Shen, Xihui1; Wang, Yao1; Yuan, Zhiming1 |
| 刊名 | Archives of microbiology
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 193期号:5页码:351-363 |
| 关键词 | Yersinia pseudotuberculosis Type vi secretion system Quorum sensing N-acylhomoserine Lactones |
| ISSN号 | 0302-8933 |
| DOI | 10.1007/s00203-011-0680-2 |
| 通讯作者 | Wang, yao(ywang@wh.iov.cn) |
| 英文摘要 | The type vi secretion system (t6ss) is a novel secretion system found in many gram-negative bacterial pathogens, which appears to be tightly regulated by different regulatory mechanisms. in the present study, we identified 4 t6ss clusters in yersinia pseudotuberculosis and demonstrated that they were differentially thermoregulated. among them, t6ss4 was preferentially expressed at 26a degrees c, and its expression was growth phase dependent and subject to quorum sensing regulation. both ypsi and ytbi ahl synthases contributed to the positive regulation of t6ss4, whereas ypsi synthase played the major role as t6ss4 expression was reduced strongly in the ypsi mutant strain but weakly in the ytbi mutant strain. moreover, we provided evidence that exogenous addition of different synthetic ahls complemented t6ss4 expression in different efficiencies in an ypsiytbi double mutant strain, suggesting c6-hsl had an antagonistic effect on t6ss4 expression. this is the first study demonstrating that the expression of t6ss is precisely regulated by temperature, growth phase, and ahl-dependent quorum sensing systems in y. pseudotuberculosis. |
| WOS关键词 | N-ACYLHOMOSERINE LACTONES ; TARGET-CELL CONTACT ; PSEUDOMONAS-AERUGINOSA ; PROTEIN SECRETION ; AGROBACTERIUM-TUMEFACIENS ; AEROMONAS-HYDROPHILA ; BIOFILM FORMATION ; CLINICAL ISOLATE ; DNA INTERACTIONS ; STRESS-RESPONSE |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000289433900005 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375902 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Yao |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weipeng,Xu, Shengjuan,Li, Jing,et al. Modulation of a thermoregulated type vi secretion system by ahl-dependent quorum sensing in yersinia pseudotuberculosis[J]. Archives of microbiology,2011,193(5):351-363. |
| APA | Zhang, Weipeng,Xu, Shengjuan,Li, Jing,Shen, Xihui,Wang, Yao,&Yuan, Zhiming.(2011).Modulation of a thermoregulated type vi secretion system by ahl-dependent quorum sensing in yersinia pseudotuberculosis.Archives of microbiology,193(5),351-363. |
| MLA | Zhang, Weipeng,et al."Modulation of a thermoregulated type vi secretion system by ahl-dependent quorum sensing in yersinia pseudotuberculosis".Archives of microbiology 193.5(2011):351-363. |
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来源：武汉病毒研究所
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