An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer
文献类型：期刊论文
| 作者 | Gao Yu-Zhe1,4; Zhang Lei1,4; Huo Wei-Song1,4; Shi Stone2; Lian Jie3; Gao Yun-Hua1 |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 43期号:6页码:802-807 |
| 关键词 | Giant magnetoresistance Microfluidic immuno-sensor D-dimer Magnetic particles |
| ISSN号 | 0253-3820 |
| DOI | 10.1016/s1872-2040(15)60827-1 |
| 通讯作者 | Gao yun-hua(yhgao@mail.ipc.ac.cn) |
| 英文摘要 | A method for rapid detection and quantification of d-dimer as a biomarker of thrombosis was developed by utilizing giant magnetoresistance (gmr) sensor integrated with microfluidic technique and 100 nm magnetic particles (mps) as signal probes. the mps binding on the chip through specific immune reaction were measured by the gmr sensor and the concentration of d-dimer was obtained at the same time. the detection range of this method was from 5 ng ml(-1) to 6500 ng ml(-1), the detection limit was 5 ng ml(-1), the intra relative standard deviation was less than 12% and the inter relative standard deviation was less than 14%. the whole analysis process could be completed within 9 min, and a good linear correlation between the results of gmr biosensor and sysmex ca1500 was obtained. the method had the advantages such as high sensitivity, fast detection and good accuracy. |
| WOS关键词 | DEEP-VEIN THROMBOSIS ; MAGNETIC NANOPARTICLES ; VENOUS THROMBOEMBOLISM ; PULMONARY-EMBOLISM ; EXCLUSION ; DIAGNOSIS ; ASSAY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000356301700001 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376749 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao Yun-Hua |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Dongguan Bosh Biotechnol LTD, Dongguan 523808, Peoples R China 3.Peoples Publ Secur Univ China, Dept Forens Sci, Beijing 10038, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao Yu-Zhe,Zhang Lei,Huo Wei-Song,et al. An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer[J]. Chinese journal of analytical chemistry,2015,43(6):802-807. |
| APA | Gao Yu-Zhe,Zhang Lei,Huo Wei-Song,Shi Stone,Lian Jie,&Gao Yun-Hua.(2015).An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer.Chinese journal of analytical chemistry,43(6),802-807. |
| MLA | Gao Yu-Zhe,et al."An integrated giant magnetoresistance microfluidic immuno-sensor for rapid detection and quantification of d-dimer".Chinese journal of analytical chemistry 43.6(2015):802-807. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。