Aggregated tau induces the inactivation and conformational changes of lactate dehydrogenase
文献类型：期刊论文
| 作者 | Tian, R; Qu, MH; Liu, Y; He, RQ |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2004-07-01 |
| 卷号 | 31期号:7页码:596-599 |
| 关键词 | Tau Self-aggregate Tubulin Assembly Lactate dehydrogenase Alzheimer's disease |
| ISSN号 | 1000-3282 |
| 通讯作者 | He, rq() |
| 英文摘要 | Human neuronal tau aggregates by incubation at 37degreesc (ph 7.2) and the aggregated tau is inactivated in promoting tubulin assembly. furthermore, aggregated tau induces inactivation and conformational changes of rabbit muscle lactate dehydrogenase, although native tau can promote ldh activity. it suggests that tau aggregation may affect the energy metabolism in which ldh is involved. |
| WOS关键词 | PROTEIN-TAU ; ALZHEIMERS-DISEASE ; ENZYMES ; BRAINS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000222914400004 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376848 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, RQ |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Lab Visual Informat Proc, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, R,Qu, MH,Liu, Y,et al. Aggregated tau induces the inactivation and conformational changes of lactate dehydrogenase[J]. Progress in biochemistry and biophysics,2004,31(7):596-599. |
| APA | Tian, R,Qu, MH,Liu, Y,&He, RQ.(2004).Aggregated tau induces the inactivation and conformational changes of lactate dehydrogenase.Progress in biochemistry and biophysics,31(7),596-599. |
| MLA | Tian, R,et al."Aggregated tau induces the inactivation and conformational changes of lactate dehydrogenase".Progress in biochemistry and biophysics 31.7(2004):596-599. |
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来源：中国科学院大学
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