Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax
文献类型：期刊论文
| 作者 | Xu, Qingsong1,3; Dou, Hangli1,3; Wei, Peng1,3; Tan, Chengyu1; Yun, Xiaojing2; Wu, Yihong2; Bal, Xuefang1; Ma, Xiaojun1; Du, Yuguang1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2008-03-07 |
| 卷号 | 71期号:4页码:509-514 |
| 关键词 | chitooligosaccharides hepatoma apoptosis Bax |
| ISSN号 | issn: 0144-8617 |
| 产权排序 | 1;1 |
| 通讯作者 | 杜昱光 |
| 英文摘要 | chitooligosaccharides (cos) have been shown to regulate various cellular and biological functions. however, the effect of cos on apoptosis of hepatocellular carcinoma cells remains unclear. in this study, the activity and mechanism of cos against human hepatocellular carcinoma cells (smmc-7721 cells) were investigated in vitro. the experiments showed that cos notably induced the apoptosis of smmc-7721 cells and increased the cleavage of poly(adp-ribose) polymerase. it presented a dose-dependent manner, and the apoptotic rate amounted to about 38% after treatment with 0.8 mg/ml cos for 72 h. the mrna and protein levels of bax were up-regulated by cos. these results demonstrated that cos induced apoptosis of smmc-7721 cells. the possible mechanism is that cos up-regulate pro-apoptotic protein bax, and trigger the cells a start-up of the apoptosis program. (c) 2007 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | water-soluble chitosan ; molecular-weight chitosans ; n-acetylchitohexaose ; oligochitosan ; expression ; protein ; growth ; mice ; link |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000253115600002 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101053]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qingsong,Dou, Hangli,Wei, Peng,et al. Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax[J]. carbohydrate polymers,2008,71(4):509-514. |
| APA | Xu, Qingsong.,Dou, Hangli.,Wei, Peng.,Tan, Chengyu.,Yun, Xiaojing.,...&Du, Yuguang.(2008).Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax.carbohydrate polymers,71(4),509-514. |
| MLA | Xu, Qingsong,et al."Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax".carbohydrate polymers 71.4(2008):509-514. |
入库方式： OAI收割
来源：大连化学物理研究所
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