Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells
文献类型：期刊论文
| 作者 | Zhang, Y; Cao, EH; Qin, JF |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2005-05-23 |
| 卷号 | 516期号:1页码:1-9 |
| 关键词 | Apoptosis Trf1 Trf2 Reactive oxygen species Arsenic trioxide Telomeric state |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2005.04.022 |
| 通讯作者 | Cao, eh(caoeh@sun5.ibp.ac.cn) |
| 英文摘要 | In this work, our study focused on as(2)o(3) action in view point of telomere. results showed that treatment of human gastric cancer mgc803 cells with arsenic trioxide could cause up-regulation of telomeric repeat binding factor trf1 and trf2 mrna and protein levels, and induced g2/m phase arrest and cell apoptosis. at the same time, telomere length shortening and telomerase inhibitory were not obvious. flow cytometry measurements indicated that the increase of trf1 and trf2 proteins is related to oxidative stress by arsenic trioxide. results also indicate that after arsenic trioxide treatment, p53 protein levels increased significantly and also could bind directly at the telomere t-loop junction. these findings demonstrate arsenic trioxide-induced cell cycle arrest and apoptosis might involve a novel pathway related to trf1, trf2 protein. (c) 2005 elsevier b.v. all rights reserved. |
| WOS关键词 | ARSENIC TRIOXIDE ; IN-VITRO ; INDUCED APOPTOSIS ; DNA ; PROTEIN ; LENGTH ; CYCLE ; LOOP ; P53 ; FIBROBLASTS |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000229849800001 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2377981 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cao, EH |
| 作者单位 | Chinese Acad Sci, Grad Sch, Acad Sinica, Inst Biophys, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Cao, EH,Qin, JF. Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells[J]. European journal of pharmacology,2005,516(1):1-9. |
| APA | Zhang, Y,Cao, EH,&Qin, JF.(2005).Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells.European journal of pharmacology,516(1),1-9. |
| MLA | Zhang, Y,et al."Up-regulation of telomere-binding trf1, trf2 related to reactive oxygen species induced by as(2)o(3) in mgc-803 cells".European journal of pharmacology 516.1(2005):1-9. |
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来源：中国科学院大学
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